Spontaneous release of interleukin-1 (IL-1) from medullary mononuclear cells of pagetic subjects

Calcified Tissue International
G PioliM Passeri

Abstract

The Authors examined interleukin 1 (IL-1) secretion from the peripheral and medullary mononuclear cells, obtained with sequential separation on Ficoll-Hypaque and 45% Percoll gradient, in 6 pagetic subjects and 6 normal controls. Both peripheral and medullary cells from pagetic subjects showed a significantly greater IL-1 production after stimulation with lipopolysaccharides (LPS); moreover, we observed a spontaneous IL-1 release from medullary cells in pagetic subjects but not in normal controls. These findings suggest a possible role of IL-1 in the elevated bone turnover of Paget's disease of bone.

References

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Citations

Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H L UyG D Roodman
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M E Cohen-SolalM C De Vernejoul
Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Pacifici
Apr 1, 1992·Calcified Tissue International·R Pacifici
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Dec 4, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giordano DicuonzoGiuseppe Tonini
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R M ArisG E Lester
Dec 21, 2013·International Immunopharmacology·Gláucio Ricardo Werner de CastroTânia Silvia Fröde

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