PMID: 6159555Nov 27, 1980Paper

Spontaneous remission of autoimmune encephalomyelitis is inhibited by splenectomy, thymectomy or ageing

Nature
A Ben-NunI R Cohen

Abstract

Experimental autoimmune encephalomyelitis (EAE) can be induced in genetically susceptible animals by injecting them with basic protein of myelin (BP) in a suitable adjuvant. EAE in adult Lewis rats is expressed clinically by acute paralysis and histologically by mononuclear cell infiltration of the central nervous system. Most rats spontaneously recover from EAE and show little or no damage to myelin. We report here that chronic progressive EAE with marked myelin lesions can be induced by a single injection of BP in complete Freund's adjuvant in intact 13-month old rats, or in 4-month old rats provided they have been splenectomized. Juvenile 2 1/2-month old rats recover spontaneously despite splenectomy. Thymectomy of young adult rats leads to relapsing EAE. These results illustrate that the clinical course of EAE is markedly influenced by age and integrity of immune organs. Furthermore, they provide an experimental model with features similar to those of chronic relapsing disease of the nervous system of man.

References

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Citations

Nov 1, 1987·Journal of the Neurological Sciences·G K HarveyJ Antony
Aug 23, 2001·International Immunopharmacology·R C van der Veen
Nov 16, 2004·Journal of Immune Based Therapies and Vaccines·Cristina MusselliMaurizio Zanetti
Jan 1, 1988·Journal of Neuroimmunology·S Sriram, L Carroll
Jan 1, 1993·International Reviews of Immunology·I R Cohen, F Mor
Jan 20, 2016·CPT: Pharmacometrics & Systems Pharmacology·J CosgroveM Coles
Feb 27, 2007·The American Journal of Pathology·Jens van den BrandtHolger M Reichardt
Aug 17, 2014·Experimental Gerontology·Jasmina DjikićGordana Leposavić
Jan 18, 2015·Journal of Neuroimmunology·Jasmina DjikićGordana Leposavić
Sep 16, 2016·Journal of the Royal Society, Interface·Mark N ReadJon Timmis
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xi ChenJingwu Z Zhang
Jun 26, 2021·Current Protocols·Paul Smith

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