Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

Veterinary Pathology
B K ChaffeeC R Abee

Abstract

Chimpanzees (Pan troglodytes) have served as an important model for studies of reproductive diseases and aging-related disorders in humans. However, limited information is available about spontaneously occurring reproductive tract lesions in aging chimpanzees. In this article, the authors present histopathologic descriptions of lesions identified in the reproductive tract, including the mammary gland, of 33 female and 34 male aged chimpanzees from 3 captive populations. The most common findings in female chimpanzees were ovarian atrophy, uterine leiomyoma, adenomyosis, and endometrial atrophy. The most common findings in male chimpanzees were seminiferous tubule degeneration and lymphocytic infiltrates in the prostate gland. Other less common lesions included an ovarian granulosa cell tumor, cystic endometrial hyperplasia, an endometrial polyp, uterine artery hypertrophy and mineralization, atrophic vaginitis, mammary gland inflammation, prostatic epithelial hyperplasia, dilated seminal vesicles, a sperm granuloma, and lymphocytic infiltrates in the epididymis. The findings in this study closely mimic changes described in the reproductive tract of aged humans, with the exception of a lack of malignant changes observed in the ma...Continue Reading

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Citations

Apr 19, 2017·Journal of Medical Primatology·Hannah LaurenceEdward J Dick
Mar 5, 2016·Veterinary Pathology·J M WardP M Treuting
Feb 17, 2018·Veterinary Pathology·James K ChambersKazuyuki Uchida
Aug 18, 2018·Nature Reviews. Cancer·Patricia A PesaventoKevin D Woolard
May 26, 2017·Journal of Medical Primatology·Shyamesh KumarEdward J Dick
Nov 20, 2020·Veterinary Pathology·Shannon KirejczykSanjeev Gumber
Sep 14, 2021·American Journal of Primatology·Anneke MorescoDalen W Agnew

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Methods Mentioned

BETA
hysterectomy
contraception

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