PMID: 3757938Sep 1, 1986Paper

Spontaneous rhythmic synchronous activity in epileptic human and normal monkey temporal lobe

Epilepsia
P A Schwartzkroin, M M Haglund

Abstract

Intracellular recordings were obtained from neurons in tissue taken from human epileptic temporal lobe and normal monkey hippocampus. Using the in vitro slice preparation, we confirmed that spontaneous rhythmic synchronous events (SRSEs) were predominantly found in cells of mesial temporal lobe. These synaptic-like events appeared to be mediated by a GABAergic mechanism, since they were blocked by bicuculline. An interneuron-like cell type was found which discharged in a burst pattern in parallel with SRSE occurrence in pyramidal neurons. Burst discharges were graded and excitatory postsynaptic potential (EPSP)-triggered; all-or-none paroxysmal depolarizations were extremely rare. These features of SRSE activity suggest that population synchrony in this tissue is largely dependent on local inhibitory interneuronal circuitry. SRSEs were found in normal monkey hippocampus as well as in mesial tissue from human epileptic temporal lobe. This result indicates that SRSEs are not a direct reflection of tissue epileptogenicity. However, the circuitry underlying SRSEs may be important in the determination of tissue seizure susceptibility, since it provides a substrate for cell synchronization.

References

Nov 17, 1978·Brain Research·P A Schwartzkroin, L H Mathers
May 19, 1978·Brain Research·P A Schwartzkroin, D A Prince
Jun 3, 1977·Brain Research·P A Schwartzkroin
Oct 22, 1976·Brain Research·P A Schwartzkroin, D A Prince
Aug 29, 1975·Brain Research·B H BlandT Ganes
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Sep 1, 1984·Cellular and Molecular Neurobiology·W D KnowlesP A Schwartzkroin
Mar 1, 1984·Pacing and Clinical Electrophysiology : PACE·J D FisherL E Waspe
Jun 1, 1984·Electroencephalography and Clinical Neurophysiology·J LermaJ M Solís
Dec 1, 1982·Journal of Neurophysiology·B W ConnorsD A Prince
Apr 6, 1981·Brain Research·D A Prince, R K Wong
Jan 1, 1981·Experimental Brain Research·J J Hablitz
Mar 1, 1983·Annals of Neurology·P A SchwartzkroinA R Wyler
Jun 3, 1982·Brain Research·M GalvanG ten Bruggencate
Oct 1, 1981·Journal of Neurophysiology·T H BrownD H Perkel
Mar 3, 1980·Brain Research·P A Schwartzkroin, D A Prince
Aug 1, 1980·The Journal of Physiology·R Dingledine, L Gjerstad
Feb 1, 1981·Experimental Neurology·J J Hablitz, A Lundervold

❮ Previous
Next ❯

Citations

Jan 1, 1996·Hippocampus·R GrangerG Lynch
Mar 1, 1991·Neurochemical Research·J G Tasker, F E Dudek
Sep 24, 2005·Anatomy and Embryology·A GorjiE-J Speckmann
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Jan 1, 1991·Progress in Neurobiology·E W LothmanJ L Stringer
Apr 1, 1996·Progress in Neurobiology·M Avoli, A Williamson
Aug 14, 1989·Neuroscience Letters·J H SchneidermanA Advani
May 1, 1989·Epilepsy Research·M Isokawa-AkessonT L Babb
Mar 1, 1994·Epilepsy Research·P A Schwartzkroin
Jul 1, 1995·Epilepsy Research·V Valenzuela, L S Benardo
Feb 13, 2001·Progress in Neurobiology·M de Curtis, G Avanzini
Jul 17, 2001·The European Journal of Neuroscience·F K SkinnerL Zhang
Dec 4, 2002·Epilepsia·Ali GorjiErwin-Joseph Speckmann
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jacques J LaschetRené Pumain
Apr 19, 2008·Neuro-Chirurgie·G HuberfeldR Miles
Apr 21, 2001·The Journal of Physiology·S Karnup, A Stelzer
Apr 17, 2002·The Journal of Physiology·Chiping WuLiang Zhang
Apr 1, 2003·The Journal of Physiology·L Menendez de la Prida
Jan 7, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Radwa A B BadawyRichard A L Macdonell
Jun 5, 2007·Seminars in Pediatric Neurology·Kristina A FenoglioJohn F Kerrigan
May 10, 2005·Journal of Neuroscience Research·Uwe-Robert KochRüdiger Köhling
Jun 26, 2004·The European Journal of Neuroscience·Ali Gorji, Erwin-Josef Speckmann
Sep 11, 2009·Annals of Neurology·Roman TyzioRoustem Khazipov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.