Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice.

Neuroscience
M L PierceSusan A Deuchars

Abstract

Neuronal networks generating rhythmic activity as an emergent property are common throughout the nervous system. Some are responsible for rhythmic behaviours, as is the case for the spinal cord locomotor networks; however, for others the function is more subtle and usually involves information processing and/or transfer. An example of the latter is sympathetic nerve activity, which is synchronized into rhythmic bursts in vivo. This arrangement is postulated to offer improved control of target organ responses compared to tonic nerve activity. Traditionally, oscillogenic circuits in the brainstem are credited with generating these rhythms, despite evidence for the persistence of some frequencies in spinalized preparations. Here, we show that rhythmic population activity can be recorded from the intermediolateral cell column (IML) of thoracic spinal cord slices. Recorded in slices from 10- to 12-day-old rats, this activity was manifest as 8-22 Hz oscillations in the field potential and was spatially restricted to the IML. Oscillations often occurred spontaneously, but could also be induced by application of 5-HT, α-methyl 5-HT or MK212. These agents also significantly increased the strength of spontaneous oscillations. Rhythmic ac...Continue Reading

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Citations

Feb 7, 2015·Experimental Physiology·Susan A Deuchars
Sep 4, 2014·Frontiers in Physiology·Débora de CarvalhoLuciane H Gargaglioni
Aug 30, 2016·Autonomic Neuroscience : Basic & Clinical·J H Coote, R A Chauhan
May 24, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Varinder K LallSusan A Deuchars
Jan 29, 2019·Frontiers in Neuroscience·Tijana Bojić
Apr 8, 2020·Frontiers in Physiology·Richard Ang, Nephtali Marina

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