PMID: 9659157Jul 11, 1998Paper

Spontaneous secretion of interferon gamma and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes

Gut
M CarolF Mascart-Lemone

Abstract

Cytokines secreted by intestinal T lymphocytes probably play a critical role in regulation of the gut associated immune responses. To quantify interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secreting cells (SC) among human intraepithelial (IEL) and lamina propria (LPL) lymphocytes from the duodenum and right colon in non-pathological situations and in the absence of in vitro stimulation. Duodenal and right colonic biopsy specimens were obtained from patients with no inflammation of the intestinal mucosa. Intraepithelial and lamina propria cell suspensions were assayed for numbers of cells spontaneously secreting IFN-gamma and IL-4 by a two site reverse enzyme linked immunospot technique (ELISPOT). The relatively high proportion of duodenal lymphocytes spontaneously secreting IFN-gamma (IEL 3.6%; LPL 1.9%) and IL-4 (IEL 1.3%; LPL 0.7%) contrasted with the very low numbers of spontaneously IFN-gamma SC and the absence of spontaneously IL-4 SC among peripheral blood mononuclear cells. In the basal state, both IFN-gamma and IL-4 were mainly produced by CD4+ cells. Within the colon, only 0.2% of IEL and LPL secreted IFN-gamma in the basal state, and 0.1% secreted IL-4. Compared with peripheral lymphocytes substantial proporti...Continue Reading

References

Nov 25, 1992·Journal of Immunological Methods·R L Mosley, J R Klein
Jan 1, 1991·The Journal of Experimental Medicine·S Ehlers, K A Smith
Feb 1, 1987·Scandinavian Journal of Immunology·L M SollidE Thorsby
Sep 1, 1993·European Journal of Immunology·F PowrieR L Coffman

❮ Previous
Next ❯

Citations

Apr 7, 2005·Digestive Diseases and Sciences·Francisco LeónGarbiñe Roy
Nov 19, 2013·Fish & Shellfish Immunology·Fumio TakizawaUwe Fischer
Aug 2, 2003·Gastroenterology·Francisco LeónGarbiñe Roy
Oct 26, 1999·Immunology Today·T T MacDonaldS L Pender
Sep 21, 2002·Molecular and Cellular Endocrinology·A Rincheval-ArnoldJ Djiane
Apr 27, 2001·Trends in Immunology·T T MacDonald, G Monteleone
May 2, 2002·Clinical and Experimental Immunology·M Westerholm-OrmioE Savilahti
Nov 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B BylF Mascart-Lemone
Oct 7, 2006·Current Opinion in Gastroenterology·E Isolauri
Jun 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Gabor VeresErkki Savilahti
Jan 12, 2005·Clinical and Diagnostic Laboratory Immunology·Geeta RameshKarol Sestak
Apr 25, 2012·PloS One·Marina L Ritchie, Tamara N Romanuk
Apr 7, 2010·American Journal of Veterinary Research·Eveline Z VeenhofTon Willemse
Jan 14, 2009·World Journal of Gastroenterology : WJG·Lin Lin ChenFang Gen Lu
Mar 19, 2005·Pediatric Research·Francisco J Pérez-CanoMargarida Castell
Nov 17, 2001·European Journal of Gastroenterology & Hepatology·A M VeitchM J Farthing
May 11, 2010·Immunological Investigations·Amit A LugadeYasmin Thanavala
Jul 26, 2011·Expert Review of Gastroenterology & Hepatology·Umberto VoltaGiacomo Caio
Aug 1, 2005·Reumatología clinica·Y Richaud-PatinL Llorente
Feb 5, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B MarottiG Nardone
Jul 4, 2003·Paediatric and Perinatal Epidemiology·Devendra K Amre, Ernest G Seidman
Sep 13, 2003·Parasite Immunology·Thomas T MacDonald
Dec 2, 2008·Clinical and Experimental Immunology·S HirosakoH Kohrogi
Dec 18, 2013·Immunology·Andrew J McDermott, Gary B Huffnagle
Mar 9, 2012·Clinical & Developmental Immunology·Maristela RubertiWirla Maria da Silva Cunha Tamashiro
Jan 10, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F R MachadoM I S Duarte
Oct 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Frauke BatailleAnja-Katrin Bosserhoff
Jul 13, 2017·Scandinavian Journal of Gastroenterology·Bani AhluwaliaLena Öhman
Mar 14, 2018·ChemistryOpen·Karen M LammersVeronica I Dodero
Apr 28, 2006·Journal of Leukocyte Biology·Monica CarolJuan-R Malagelada
Apr 2, 2003·Nature Reviews. Immunology·Allan McI Mowat
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamal I SaadaDon W Powell
Dec 30, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Temitope O KekuXuesong Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.