Spontaneous synaptic activity in chick vestibular nucleus neurons during the perinatal period

Neuroscience
Mei ShaoK D Peusner

Abstract

The principal cells of the chick tangential nucleus are second-order vestibular neurons involved in the vestibuloocular and vestibulocollic reflexes. The spontaneous synaptic activity of morphologically identified principal cells was characterized in brain slices from 1-day-old hatchlings (H1) using whole-cell voltage-clamp recordings and Cs-gluconate pipet solution. The frequency was 1.45 Hz for spontaneous excitatory postsynaptic currents (sEPSCs) and 1.47 Hz for spontaneous inhibitory postsynaptic currents (sIPSCs). Using specific neurotransmitter receptor antagonists, all of the sEPSCs were identified as AMPA receptor-mediated events, whereas 56% of the sIPSCs were glycine and 44% were GABA(A) receptor-mediated events. On exposure to TTX, the frequency of EPSCs decreased by 68%, while the frequency of IPSCs decreased by 33%, indicating greater EPSC dependency on presynaptic action potentials. These data on spontaneous synaptic activity at H1 were compared with those obtained in previous studies of 16-day old embryos (E16). After birth, the spontaneous synaptic activity exhibited increased EPSC frequency, increased ratio for excitatory to inhibitory events, increased percentage of TTX-dependent EPSCs, and faster kinetics. In...Continue Reading

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May 13, 2004·Journal of Neuroscience Research·Anastas PopratiloffKenna D Peusner

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Citations

Sep 12, 2013·Case Reports in Urology·Antonio MarteFiorina Casale
Apr 9, 2008·Journal of Chemical Neuroanatomy·Maria F PassettoCláudio A B Toledo
Oct 18, 2007·Journal of Neuroscience Research·M ShaoK D Peusner
Aug 26, 2009·Journal of Neuroscience Research·Adria Gottesman-Davis, Kenna D Peusner
May 13, 2006·Neuroscience·M ShaoK D Peusner
Dec 7, 2010·Neuroscience·A Popratiloff, K D Peusner
Jun 16, 2006·Journal of Neurophysiology·Mei ShaoKenna D Peusner

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