PMID: 9546247Apr 18, 1998Paper

Spontaneous tibial artery thrombosis associated with varicella pneumonia and free protein S deficiency

Journal of Vascular Surgery
B D PeytonF M Stewart

Abstract

Pneumonia is the most common serious complication of varicella infection in adults. A variety of thrombotic complications including purpura fulminans and disseminated intravascular coagulation have been reported in children with varicella but not in adults. Two men with varicella pneumonia who had profound lower extremity ischemia caused by thrombosis of the profunda femoris and tibial arteries are reported. Both patients had free protein S deficiency and vascular thrombosis in association with varicella pneumonia without overt evidence of disseminated intravascular coagulation or purpura fulminans. Antiphospholipid immunoglobulin G and immunoglobulin M antibodies were present in one, whereas the other had evidence of the lupus anticoagulant. The proposed pathogenesis and management options including intraarterial thrombolytic therapy with urokinase and the need for long-term anticoagulation are discussed.

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Citations

Apr 16, 2003·Annals of the Rheumatic Diseases·R A Asherson, R Cervera
Nov 5, 2002·Annual Review of Medicine·Jacob H Rand
Apr 29, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·J Limb, A Binning
Jan 17, 2013·Hematology·Mara FerraraL Capozzi
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Aug 3, 2010·The Journal of Rheumatology·Mehmet Engin TezcanMehmet Akif Oztürk
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Oct 18, 2000·Spine·S R Garfin
Apr 26, 2020·Current Opinion in Infectious Diseases·Maria A NagelAndrew N Bubak
May 14, 2014·Current Infectious Disease Reports·Maria A Nagel, Don Gilden
Aug 17, 2012·The Pediatric Infectious Disease Journal·Fatma RabahAnil Pathare
Mar 21, 2007·Journal of the American Podiatric Medical Association·Krista A ArcherJonathan A Haber
Feb 12, 2002·Seminars in Arthritis and Rheumatism·Imad W Uthman, Azzudin E Gharavi

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