Spontaneous treatment discontinuation in panic disorder patients treated with antidepressants

Acta Psychiatrica Scandinavica
Cristina ToniHagop S Akiskal

Abstract

We examined the relationships between long-term treatment response, side-effects and drug discontinuation in panic disorder (PD)-agoraphobia. A total of 326 patients were naturalistically treated with antidepressants and followed for a period of 3 years. All patients were evaluated by means of the Panic Disorder/Agoraphobia Interview and the Longitudinal Interview Follow-up Examination (LIFE-UP). A total of 179 patients interrupted pharmacological treatment. Among them, 26.8% were not traceable; 36.9% had deemed further contact with the psychiatrist unnecessary because of remission. Other reasons for interruption were: ineffectiveness (18.4%), side-effects (10.6%) and personal reasons (7.3%). Patients who interrupted pharmacological treatment because of symptom remission remained in the study for a longer period than those patients who interrupted their treatment because of inefficacy. In the long-term treatment of PD with antidepressants, a high percentage of patients who have achieved symptom remission tend to default from further treatment; adherence to long-term treatment with antidepressants was predicted by severe and long-lasting symptomatology.

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Citations

Nov 3, 2010·Psychiatry and Clinical Neurosciences·Massimiliano BuoliCarlo Altamura
Sep 29, 2011·Patient Preference and Adherence·Lívia Santana, Leonardo F Fontenelle
May 9, 2006·Acta Psychiatrica Scandinavica·S RambelomananaN Moore
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Neeltje M BatelaanDan J Stein
Oct 3, 2006·Behaviour Research and Therapy·Christopher J Graver, Patricia M White
Jul 11, 2009·Expert Review of Neurotherapeutics·Maurizio PompiliDavid Lester

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