Spontaneous tumors in aged SD-JCL rats (author's transl)

Jikken dobutsu. Experimental animals
Y MuraokaY Hayashi

Abstract

Incidence of spontaneous tumors was examined in 77 male and 73 female SD-JCL rats reared throughout their lifespan of 5 to 36 months. Total tumor incidences were 60% and 95% for males and females, respectively. The sex difference was mostly attributable to a high incidence of mammary tumor in females. The pituitary tumor was found in 30% of males and 66% of females aged 5 to 36 months while islet cell tumor of the pancreas and thyroid tumor occurred later and the incidence of latter was particularly high in rats lived more than 2 years. Myeloid leukemia appeared to occur as early as 5 months of age.

Citations

May 31, 2001·Experimental Animals·M NakazawaN Sumi
May 18, 2016·Journal of Toxicologic Pathology·Takashi OgawaMorimichi Hayashi
Jan 28, 2010·Geriatrics & Gerontology International·Kazunao KuramotoTadashi Shinkai

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