Spontaneous variability of complex ventricular arrhythmias detected by long-term electrocardiographic recording

E L Michelson, J Morganroth


Variations in the frequency of complex ventricular arrhythmias were evaluated by consecutive 24-hour long-term electrocardiographic recordings over 4 days using a two-channel recorder and computer-assisted analysis system with a weighted relative mean error of 7.5 +/ 5% (SD). Twenty patients (mean age 58 +/- 9 years [SD] with various cardiac disorders were selected if they had a daily average of more than 30 ventricular ectopic complexes per hour. Twenty patients had ventricular couplets and 14 patients had ventricular tachycardia (at least triplets). The mean daily number of either couplets or ventricular tachycardia was subjected a four-factor nested analysis of variance to determine the sources of variation in ectopic frequency. Differences in hourly rates accounted for 30% of the variation in the frequency of ectopic complexes. Statistical methods were applied to determine the change in frequency of complex arrhythmias necessary to exceed that attributable to spontaneous variation alone at the p less than 0.05 level. Using a typical protocol, for example, comparing a 24-hour test period with a 24-hour control period would require a 65% decrease in mean hourly frequency of ventricular tachycardia and 75% reduction in the fr...Continue Reading


Oct 6, 1977·The New England Journal of Medicine·W RubermanS Shapiro
May 22, 1978·The American Journal of Cardiology·D C HarrisonR A Winkle
May 1, 1974·Progress in Cardiovascular Diseases·S B BleiferH L Harold


Mar 1, 1991·Journal of Clinical Pharmacology·M J FrankR L Manwaring
Jan 1, 1992·Biological cybernetics·F Ravelli, R Antolini
Jan 1, 1983·European Journal of Clinical Pharmacology·M ChiarielloM Condorelli
Jul 1, 1981·American Heart Journal·D N MohrJ E Markis
Sep 1, 1984·The American Journal of Cardiology·G V NaccarelliR A Goldstein
Aug 1, 1982·Computers and Biomedical Research, an International Journal·A R LeBlancR A Nadeau
Mar 15, 1995·Journal of the American College of Cardiology·M A WoodK A Ellenbogen
Jul 1, 1994·Journal of the American College of Cardiology·N Sydney MoïseB Kornreich
Mar 1, 1983·The American Journal of Cardiology·A H GradmanB L Zaret
Apr 1, 1985·Journal of the American College of Cardiology·D L MannM M LeWinter
May 17, 2000·Journal of Clinical Epidemiology·K R EvensonR J Simpson
Jan 29, 1981·The New England Journal of Medicine·A D Angeletti
Mar 1, 1994·Pacing and Clinical Electrophysiology : PACE·A J Camm, L Fei
Sep 1, 1990·The American Journal of the Medical Sciences·W G Thompson
Sep 1, 1988·The American Journal of the Medical Sciences·M S Kremers
Feb 1, 1990·Chest·S N SteenT R MacGregor
Jul 29, 2010·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Anna R M GelzerN Sydney Moïse
Jul 31, 2007·Advanced Drug Delivery Reviews·Francesco Portaluppi, Ramón C Hermida
Sep 6, 2012·Scandinavian Journal of Medicine & Science in Sports·L CaselliA Michelucci
Jun 1, 1990·The American Journal of Cardiology·J McClellandJ McAnulty
Feb 20, 1990·The American Journal of Cardiology·S A Mahler, R M Borland

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.