Spontaneous vesicle formation in catanionic mixtures of amino acid-based surfactants: chain length symmetry effects

Langmuir : the ACS Journal of Surfaces and Colloids
Eduardo F MarquesOlle Söderman

Abstract

The use of amino acids for the synthesis of novel surfactants with vesicle-forming properties potentially enhances the biocompatibility levels needed for a viable alternative to conventional lipid vesicles. In this work, the formation and characterization of catanionic vesicles by newly synthesized lysine- and serine-derived surfactants have been investigated by means of phase behavior mapping and PFG-NMR diffusometry and cryo-TEM methods. The lysine-derived surfactants are double-chained anionic molecules bearing a pseudogemini configuration, whereas the serine-derived amphiphile is cationic and single-chained. Vesicles form in the cationic-rich side for narrow mixing ratios of the two amphiphiles. Two pairs of systems were studied: one symmetric with equal chain lengths, 2C12/C12, and the other highly asymmetric with 2C8/C16 chains, where the serine-based surfactant has the longest chain. Different mechanisms of the vesicle-to-micelle transition were found, depending on symmetry: the 2C12/C12 system entails limited micellar growth and intermediate phase separation, whereas the 2C8/C16 system shows a continuous transition involving large wormlike micelles. The results are interpreted on the basis of currently available models ...Continue Reading

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Citations

Apr 6, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Sampad GhoshJoykrishna Dey
Feb 26, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Fabiola SciscioneCamillo La Mesa
Feb 4, 2014·The Journal of Physical Chemistry. B·Jianfeng Shi, Xinghai Shen
May 5, 2011·Chemistry and Physics of Lipids·Mariusz KepczynskiMaria Nowakowska
Jun 3, 2009·Journal of Colloid and Interface Science·Yun YanJianbin Huang
Jan 29, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Anshupriya ShomePrasanta K Das
Aug 3, 2013·The Journal of Physical Chemistry. B·Rodrigo O BritoEduardo F Marques
Dec 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Kadla R RosholmOle G Mouritsen
Sep 17, 2011·The Journal of Physical Chemistry. B·Aurelio BarbettaCamillo La Mesa
Sep 24, 2016·The Journal of Physical Chemistry. B·Ravi BhattaraiAmiya Kumar Panda
Jul 5, 2018·Physical Chemistry Chemical Physics : PCCP·Maria Chiara di GregorioLuciano Galantini
Sep 20, 2011·Chemical Communications : Chem Comm·Qiongbo ZhouXiaohai Zhou
Mar 17, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Sang Hyuk SeoJi Young Chang
Jan 9, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Mariusz KepczynskiMaria Nowakowska
Jun 4, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Antonio StoccoDominique Langevin
Sep 29, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Bruno F B SilvaRamon Pons
Jul 7, 2020·The Journal of Physical Chemistry Letters·Saffron J BryantGregory G Warr

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