Spontaneously hypertensive rats: a potential model to identify drugs for treatment of learning disorders

Hypertension
A Meneses, E Hong

Abstract

Spontaneously hypertensive rats (SHR) of 3 to 12 months of age learned and retrieved less information than normotensive Wistar-Kyoto rats (WKY), although no difference was found with animals from 18 and 24 months of age. The combined influence of hypertension and aging had an additive detrimental effect on cognitive functions. Notwithstanding these deficiencies in learning and memory, SHR have seldom been used as a model in the screening of drugs with therapeutic potential for treatment of disorders of cognitive processes. Moreover, the calcium channel blocker nimodipine has beneficial effects on learning in both aged and hypertensive animals and humans. However, no attempt has been made to investigate whether nimodipine can reverse the additive deleterious effects of aging and hypertension in the same subject. We recently reported that deteriorated animals (middle-aged and/or hypertensive) chronically treated with nimodipine (via osmotic minipumps) exhibit higher learning scores. This information indicates that nimodipine can reverse the impairing effects of either aging or hypertension on learning; the presence of the two conditions, however, produces a severe impairment that can be partially reversed by this drug. Therefore,...Continue Reading

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Citations

Oct 25, 2008·Cellular and Molecular Neurobiology·Merari F R FerrariDébora R Fior-Chadi
Jun 16, 2004·Behavioural Brain Research·A MenesesC Castillo
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·A Meneses
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Meneses
May 10, 2003·Neurobiology of Learning and Memory·N M W J De BruinL M Broersen
May 20, 2011·Reviews in the Neurosciences·Alfredo MenesesCarlos Castillo
Jun 16, 2004·Clinical and Experimental Hypertension : CHE·Fiorenzo MigniniFrancesco Amenta
Nov 19, 2005·Mechanisms of Ageing and Development·Seyed Khosrow Tayebati
Dec 3, 2014·European Journal of Pharmacology·Sobhana George Sugin Lal JabarisChidambaram Saravana Babu
Jun 26, 2012·Journal of the Neurological Sciences·Seyed Khosrow TayebatiFrancesco Amenta
Jul 7, 2016·Journal of the South African Veterinary Association·Rosemarie U HöflerAnand Nadar
Jun 27, 2019·International Journal of Molecular Sciences·Da-Tong JuChih-Yang Huang
Jun 23, 2020·Clinical and Experimental Pharmacology & Physiology·Liliane Barreto da SilvaDarízy Flávia Silva

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