Spontaneously occurring cardiovascular lesions in commonly used laboratory animals

Cardio-Oncology
Eugene Herman, Sandy Eldridge

Abstract

The search for new chemical entities which are clinically effective and do not adversely affect the cardiovascular system is an ongoing objective. In vivo studies designed to detect potential drug-induced cardiovascular toxicity typically utilize both rodent and non-rodent species. An important component of such studies includes the microscopic evaluation of tissues for histopathologic changes. A factor which could potentially complicate this type of evaluation relates to the potential for laboratory animals to develop natural or spontaneous pathological cardiovascular lesions. Some types of these naturally occurring alterations are similar to those induced by chemical compounds and thus could confound accurate interpretation. Accurate morphologic analysis becomes contingent upon the ability to distinguish spontaneous cardiovascular changes from actual drug-induced lesions. A summary of some of the more frequently reported spontaneous cardiovascular alterations in commonly-used laboratory animals is presented below. Special emphasis is given to the spectrum of spontaneous background myocardial pathology that might be encountered during preclinical studies conducted to identify potential cardiotoxic actions of anticancer agents.

References

Jan 1, 1979·Journal of Comparative Pathology·J W Mullink, G T Haneveld
Oct 1, 1992·Jikken dobutsu. Experimental animals·T ItoH Miyajima
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·C AgenM Del Tacca
Jan 1, 1989·Toxicologic Pathology·S P Bishop
Jan 1, 1989·Toxicologic Pathology·D F Kelly
Jan 1, 1989·Toxicologic Pathology·H A Hartman
Mar 1, 1987·Journal of Comparative Pathology·A Spencer, P Greaves
Oct 1, 1987·Laboratory Animals·M Hewicker, G Trautwein
Jan 1, 1986·Laboratory Animals·N MaedaT Mitsuoka
Jan 1, 1974·Advances in Cardiology·B C Zook
Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Jan 1, 1974·Veterinary Pathology·G H Hottendorf, R S Hirth
Sep 8, 1965·Annals of the New York Academy of Sciences·H Luginbühl, K Detweiler
Jul 10, 1968·Annals of the New York Academy of Sciences·B M Wagner
Jan 1, 1970·Cardiovascular Research·A Pomerance, J C Whitney
Dec 1, 1982·Nihon juigaku zasshi. The Japanese journal of veterinary science·Y OghisoH Iida
Jul 1, 1995·Veterinary Pathology·P W SnyderP J Felsburg
Jan 1, 1993·Toxicologic Pathology·S FujihiraH Mori
Jun 30, 1998·Virchows Archiv : an International Journal of Pathology·M HirasawaK Kawamura
Mar 18, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Y T ChiuR Chu
Dec 21, 2000·Current Rheumatology Reports·I G Luzina, B S Handwerger
Feb 25, 2003·Toxicologic Pathology·Frances A S ClemoMudher A Albassam
Mar 2, 2006·Toxicologic Pathology·Charlotte M Keenan, Justin D Vidal
May 27, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ove Svendsen
Jul 18, 2006·Toxicologic Pathology·Ronnie ChamanzaAlys E Bradley
Jul 19, 2006·Veterinary Pathology·K A MarateaG W Stevenson
Jul 27, 2006·Human & Experimental Toxicology·P TsibiribiQ Timour
May 25, 2007·Current Heart Failure Reports·Lisa M Freeman, John E Rush
Aug 2, 2008·Journal of Medical Primatology·Brittany M SeilerGene B Hubbard
May 29, 2009·Toxicologic Pathology·Yuval RamotAbraham Nyska
Aug 27, 2009·Toxicologic Pathology·Tanja S ZabkaMudher A Albassam
Sep 29, 2009·Journal of Veterinary Internal Medicine·C AtkinsR Stepien
Feb 4, 2010·Toxicologic Pathology·Justin D VidalHeath C Thomas
Dec 7, 2010·Leukemia Research·Armin WolfDanielle Roman
Sep 23, 2011·Toxicologic Pathology·Eugene H HermanJun Zhang
Sep 29, 2011·Breast Cancer Research and Treatment·Carmine FedeleClaudia De Lorenzo
Nov 8, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ryota TochinaiKimiyuki Kaneko
Apr 11, 2014·Circulation Research·Jason M DuranSteven R Houser
Jun 19, 2014·Toxicologic Pathology·Gitte Jeppesen, Mikala Skydsgaard
Oct 1, 1994·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·S K LiuP C Yang
Sep 12, 2015·Toxicologic Pathology·Natalie D KeirsteadIgor Mikaelian

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