Sporadic bilateral adrenal medullary hyperplasia: apparent false positive MIBG scan and expected MRI findings

European Journal of Radiology
B C YungJ C Chan

Abstract

Adrenal medullary hyperplasia is a rare cause of clinical symptoms and biochemical findings identical to pheochromocytoma occurring mostly in multiple endocrine neoplasia patients. The scenario of positive MIBG scan, but no focal lesion found on CT and MRI led to diagnostic and management difficulties. Like pheochromocytoma, surgical excision can lead to clinical and biochemical recovery. We report this unusual case of sporadic bilateral adrenal medullary hyperplasia, with hypertension and biochemical abnormalities alleviated after surgical adrenalectomy. Based on T2 values reported in literature, high signal focal lesions may not appear on T2-weighted MRI images until development of frank pheochromocytoma. MIBG scan remains the most sensitive imaging modality for this condition.

References

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Citations

Aug 22, 2008·Clinical Nuclear Medicine·Giorgio TregliaVittoria Rufini
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Andrew F ScarsbrookRachel R Phillips
Nov 25, 2003·AJR. American Journal of Roentgenology·Michael A BlakePeter F Hahn
Sep 24, 2014·International Journal of Endocrinology·Lu YangTianyong Fan
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Maria Adelaide A PereiraAntonio Marmo Lucon

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