Sporadic multiple cerebral cavernomatosis: report of a case and review of literature

The Neurologist
Arzu CobanAysen Gokyigit

Abstract

Cerebral cavernous malformations (CCM) are vascular malformations causing seizures and cerebral hemorrhages. They occur in sporadic and familial forms. Familial cases are associated with a high frequency of multiple lesions, which are less frequently associated with sporadic cases. We report a 46-year-old woman presenting with epilepsy with multiple cerebral cavernomatosis on MRI. Because she had had a previous liver transplantation operation, and received immunosuppressants, she was not advised to have a brain operation. However, she had to be operated as a result of a bleeding in one of her cerebral cavernomas. The histologic diagnosis was cavernoma. She has been seizure free after the operation with levetiracetam therapy for the last 17 months. She had no positive family history for both epilepsy and cavernomatosis. When multiple cerebral cavernomatosis are identified in a patient, a detailed neurologic family history should be sought despite the possibility of its being a sporadic case. Our main intention is to present a patient who is surgically controversial and to point out the importance of genetic heredity.

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Citations

Oct 1, 2013·Clinical Neurology and Neurosurgery·Churl-Su KwonChristopher S Ogilvy
Jun 15, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R Chabbchoub Ben AbdallahA Mahfoudh
Sep 24, 2013·BioMed Research International·Rosalia D'AngeloAntonina Sidoti
May 7, 2016·Journal of Neurosurgery. Pediatrics·Andrew A FanousVeetai Li
Oct 30, 2014·PloS One·Maria Sole CigoliSilvana Penco

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Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.

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