Sporadic upper urinary tract urothelial cell carcinomas: identification of interaction between toxic carcinogens and individuals genetic susceptibility

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
Pierre ColinMorgan Rouprêt

Abstract

Upper urinary tract urothelial cell carcinomas (UUT UCC) are rare sporadic tumors. Recent epidemiologic and molecular data have shown a singular susceptibility of UUT UCCs for specific risk factors. The main exogenic factors involved in UUT UCCs carcinogenesis remain tobacco and occupational exposure (aromatic amines, polycyclic hydrocarbures and chlored solvents). Enzymatic variants of detoxification system may be responsible of carcinogenesis with these toxics. Tumors induced by phenacetine consumption are decreasing since it was banned in the 1970s. Also, acid aristolochic exposure (Balkan nephropathy, Chinese Herb nephropathy) has been demonstrated to specifically induce UUT UCCs. Familial genic polymorphism of detoxification system would explain geographic distribution in endemic areas. In Taiwan, chronic arsenic exposition would constitute the main risk factor of UUT UCC. However, theses mechanisms of carcinogenesis remain unclear. The knowledge of UUT UCC development mechanisms implying toxic detoxification systems is still incomplete. To date, there is a growing body of evidence supporting that the interaction between individual genetic susceptibilities and environmental toxic exposure is a key to explain carcinogenesis...Continue Reading

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Citations

Nov 28, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·V ElaloufE Xylinas
Sep 10, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J VarinotE Comperat
Aug 27, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A OuzzaneP Colin
May 11, 2015·Biochemical Pharmacology·Sharad S SinghalSanjay Awasthi

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