Dec 26, 2015

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

Viruses
Oliver T Fackler

Abstract

The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1 accessory proteins Vif, Vpr and Vpu, Nef was, until recently, not known to antagonize the antiviral activity of a host cell restriction factor. Two recent reports now describe the host cell proteins serine incorporator 3 and 5 (SERINC3 and SERINC5) as potent inhibitors of HIV-1 particle infectivity and demonstrate that Nef counteracts these effects. These findings establish SERINC3/5 as restrictions to HIV replication in human cells and define a novel activity for the HIV pathogenesis factor Nef.

Mentioned in this Paper

Pathogenic Aspects
Vif Gene Products, Human Immunodeficiency Virus
Pathogenesis
Virus
Gene Products, nef
Hormone Receptors, Cell Surface
Pathogenesis of HIV Malignancy
Inhibitors
Virus Replication
SERINC3 gene

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