Spotlight on Interferon-beta-1b in relapsing-remitting and secondary progressive multiple sclerosis

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Paul L McCormack, Lesley J Scott

Abstract

Interferon-beta-1b (Betaseron, Betaferon) is a non-glycosylated recombinant human interferon-beta approved for high-frequency, subcutaneous (SC) administration in the treatment of multiple sclerosis (MS). Its mechanism of action is unknown, but may involve modulation of the autoimmune pathogenic processes of MS. In a randomized, double-blind trial in patients with relapsing-remitting MS (RRMS), SC interferon-beta-1b 250 micro g (8 million International Units [MIU]) every other day reduced the annual relapse rate and increased the proportion of relapse-free patients compared with placebo. It also reduced relapse severity, hospitalizations, and disease activity assessed by magnetic resonance imaging (MRI), and increased the time to first relapse. Progression of disability showed a trend towards reduction relative to placebo and baseline, but did not reach statistical significance. SC interferon-beta-1b 250 micro g every other day was shown in a randomized trial to be superior to intramuscular (IM) interferon-beta-1a 30 micro g (6 MIU) once weekly with respect to reductions in relapse-related parameters, disability progression and MRI-assessed disease activity. In patients with secondary progressive MS (SPMS), SC interferon-beta-1...Continue Reading

References

Nov 26, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S StürzebecherB Aufdembrinke
Mar 8, 2003·BMJ : British Medical Journal·Jim ChilcottUNKNOWN Cost Effectiveness of Multiple Sclerosis Therapies Study Group
Dec 21, 2004·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·G KobeltS Fredrikson

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Citations

Mar 8, 2007·Expert Review of Neurotherapeutics·Mathias Buttmann, Peter Rieckmann
Mar 30, 2010·Critical Reviews in Microbiology·Nazish Bostan, Tariq Mahmood

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