Spotlight on panitumumab in metastatic colorectal cancer

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Gillian M Keating

Abstract

Panitumumab (Vectibix) is a recombinant, fully human, IgG2 anti-epidermal growth factor receptor (EGFR) monoclonal antibody. This spotlight reviews the clinical efficacy of intravenous panitumumab in combination with chemotherapy in the first- and second-line treatment of metastatic colorectal cancer and as monotherapy in chemotherapy-refractory metastatic colorectal cancer, as well as summarizing its pharmacologic properties and tolerability. Panitumumab is indicated for use in patients with wild-type rather than mutant KRAS tumors. The efficacy of intravenous panitumumab 6 mg/kg administered every 2 weeks was examined in randomized, open-label, multicenter, phase III trials in patients with metastatic colorectal cancer. When administered as first- or second-line treatment in combination with chemotherapy, panitumumab plus chemotherapy prolonged progression-free survival to a significantly greater extent than chemotherapy alone in patients with wild-type KRAS tumors; no significant between-group difference in overall survival was seen in the second-line treatment trial. In patients with mutant KRAS tumors, progression-free survival was significantly shorter with panitumumab plus oxaliplatin-based chemotherapy (FOLFOX4) than wi...Continue Reading

References

Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Kenneth A FoonGisela M Schwab
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemRafael G Amado
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea Sartore-BianchiSalvatore Siena
Mar 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafael G AmadoDavid D Chang
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federica Di NicolantonioAlberto Bardelli
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Randolph HechtRafael G Amado
Mar 17, 2009·Japanese Journal of Clinical Oncology·Kei MuroDaisuke Asahi
Sep 3, 2009·Journal of Clinical Pharmacology·Peiming MaAndrew Chow
Sep 10, 2009·Journal of the National Cancer Institute·Salvatore SienaAlberto Bardelli
Mar 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·J Randolph HechtJordan Berlin

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Citations

Feb 23, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·UNKNOWN Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group
Jul 1, 2013·Clinical Pharmacology in Drug Development·Bing-Bing YangHagen Kennecke
May 21, 2011·AJNR. American Journal of Neuroradiology·J J Gemmete, S K Mukherji

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