Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR

International Journal of Molecular Sciences
Yuji TokunagaKoh Takeuchi

Abstract

Solution NMR spectroscopy is a unique and powerful technique that has the ability to directly connect the structural dynamics of proteins in physiological conditions to their activity and function. Here, we summarize recent studies in which solution NMR contributed to the discovery of relationships between key dynamic properties of proteins and functional mechanisms in important biological systems. The capacity of NMR to quantify the dynamics of proteins over a range of time scales and to detect lowly populated protein conformations plays a critical role in its power to unveil functional protein dynamics. This analysis of dynamics is not only important for the understanding of biological function, but also in the design of specific ligands for pharmacologically important proteins. Thus, the dynamic view of structure provided by NMR is of importance in both basic and applied biology.

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Citations

Jul 29, 2020·Journal of Biomolecular NMR·Abhinav DubeyHaribabu Arthanari
Jun 26, 2020·International Journal of Molecular Sciences·Surajit BhattacharjyaHo Sup Yoon
Jul 12, 2020·Journal of Biomolecular NMR·Andras BoeszoermenyiGerhard Wagner

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
GTPases
X-ray
GTPase
SANS

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