Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.

Development
J Lesley Brown, Judith A Kassis

Abstract

The Polycomb group of proteins (PcG) is important for transcriptional repression and silencing in all higher eukaryotes. In Drosophila, PcG proteins are recruited to the DNA by Polycomb-group response elements (PREs), regulatory sequences whose activity depends on the binding of many different sequence-specific DNA-binding proteins. We previously showed that a binding site for the Sp1/KLF family of zinc-finger proteins is required for PRE activity. Here, we report that the Sp1/KLF family member Spps binds specifically to Ubx and engrailed PREs, and that Spps binds to polytene chromosomes in a pattern virtually identical to that of the PcG protein, Psc. A deletion of the Spps gene causes lethality late in development and a loss in pairing-sensitive silencing, an activity associated with PREs. Finally, the Spps mutation enhances the phenotype of pho mutants. We suggest that Spps may work with, or in parallel to, Pho to recruit PcG protein complexes to PREs.

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Citations

May 23, 2013·Omics : a Journal of Integrative Biology·Shahram GolbabapourA Hamid A Hadi
Nov 19, 2011·Development·Luis GutiérrezJürg Müller
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Payal RayJudith A Kassis
Mar 26, 2013·Developmental Biology·Heather Mason-SuaresPeter J Harte
Sep 3, 2011·Mechanisms of Development·Elizabeth A UlmHelen M Chamberlin
Mar 24, 2017·Molecular Genetics and Genomics : MGG·Juan M Calvo-MartínCarmen Segarra
Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·J Lesley BrownJudith A Kassis
Oct 31, 2013·G3 : Genes - Genomes - Genetics·Jumana AlHaj AbedRichard S Jones
Aug 6, 2017·Genetics·Judith A KassisJohn W Tamkun
Nov 9, 2019·Critical Reviews in Biochemistry and Molecular Biology·Thierry Cheutin, Giacomo Cavalli
Jun 4, 2021·BMC Biology·Maksim ErokhinDarya Chetverina

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