Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance.

Pharmaceutical Research
Joana PintoAmrit Paudel

Abstract

Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for inhaled delivery. Wet-sieving and spray-congealing were employed as innovative techniques to evaluate the impact of engineering on the particle properties of D-mannitol. To that end, the resulting powders were characterized concerning their solid-state, micromeritics and flowability. Afterwards, the engineered carrier particles were blended with inhalable size beclomethasone dipropionate to form low dose (1 wt%) DPI formulations. The in vitro aerosolization performance was evaluated using the NEXThaler®, a reservoir multi-dose device. Wet-sieving generated D-mannitol particles with a narrow particle size distribution and spray-congealing free-flowing spherical particles. The more uniform pumice particles with deep voids and clefts of wet-sieved D-mannitol (Pearl300_WS) were beneficial to drug aerosolization, only when used in combination with a ternary agent (10 wt% of 'Preblend'). When compared to the starting material, the spray-congealed D-man...Continue Reading

References

Mar 29, 2000·Journal of Pharmaceutical Sciences·A BurgerH Stöttner
Mar 29, 2005·Journal of Pharmaceutical Sciences·Tadashi FukunakaKunio Shinohara
Dec 27, 2005·International Journal of Pharmaceutics·H SteckelR Kammelar
Nov 18, 2006·International Journal of Pharmaceutics·J H KirkC G Blatchford
Aug 11, 2007·International Journal of Pharmaceutics·R GuchardiJ S Kaerger
Jul 12, 2008·International Journal of Pharmaceutics·S GarnierG Coquerel
May 27, 2009·Drug Development and Industrial Pharmacy·Antesar M Boshhiha, Nora A Urbanetz
May 5, 2011·International Journal of Pharmaceutics·Meer Saiful Hassan, Raymond Lau
Feb 22, 2012·International Journal of Pharmaceutics·Kyrre ThalbergMagnus Fransson
May 19, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E M LittringerN A Urbanetz
Jul 31, 2013·AAPS PharmSciTech·Garett Morin, Lauren Briens
Aug 16, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ahmed O ShalashMustafa M A Elsayed
Sep 12, 2015·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Francesca ButtiniIrene Pasquali
Oct 9, 2015·Current Pharmaceutical Design·Floris GrasmeijerAnne Haaije de Boer
Nov 5, 2017·International Journal of Pharmaceutics·Mats HertelRegina Scherließ
Mar 3, 2019·International Journal of Pharmaceutics·Jonas RudénGöran Alderborn
Dec 18, 2019·International Journal of Pharmaceutics·Nancy HertelRegina Scherließ
Jul 6, 2020·International Journal of Pharmaceutics·Nancy HertelRegina Scherließ

❮ Previous
Next ❯

Software Mentioned

Proteus Thermal Analysis
Windox

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.