Spray dried chitosan-EDTA superior microparticles as solid substrate for the oral delivery of amphotericin B

International Journal of Biological Macromolecules
Kuldeep SinghVikas Rana

Abstract

The present investigation was aimed at synthesis of chitosan-EDTA superior microparticles (COECH) bearing high oil adsorbing and oil desorbing properties. These superior particles were prepared by thermal amide conjugation of COO(-) group of EDTA with NH2 group of chitosan employing spray-drying technique. The synthesis was optimized using 4(2) full factorial design. The particles showed high oil adsorbing capacity as well as oil desorbing capacity with enhanced dispersive components of surface free energy as compared to Aerosil 200. In addition, these COECH microparticles showed higher amphotericin B loading capacity, enhancement in the in vitro dissolution performance (12-fold) and produces nanoemulsion in the size range of 70-90 nm. Further, the results were in consonance with those observed during ex vivo performance. Thus, the findings revealed simple synthesis of COECH microparticles that showed superior properties of solid substrate for the development of amphotericin B nanoemulsion.

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Citations

Jul 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sunil KambojVikas Rana
Apr 7, 2015·Carbohydrate Polymers·Jisheng YangJiubing Liu
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Malika Skiba-LahianiMohamed Skiba
Feb 6, 2017·Drug Delivery·Min LiuZhiwen Yang
Aug 5, 2017·Materials·Shehriar HusainSaad B Qasim
Feb 27, 2021·International Journal of Biological Macromolecules·S J Hepziba Magie JessimaSubramanian Sathy Srikandan

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