Spray dried chitosan-EDTA superior microparticles as solid substrate for the oral delivery of amphotericin B

International Journal of Biological Macromolecules
Kuldeep SinghVikas Rana


The present investigation was aimed at synthesis of chitosan-EDTA superior microparticles (COECH) bearing high oil adsorbing and oil desorbing properties. These superior particles were prepared by thermal amide conjugation of COO(-) group of EDTA with NH2 group of chitosan employing spray-drying technique. The synthesis was optimized using 4(2) full factorial design. The particles showed high oil adsorbing capacity as well as oil desorbing capacity with enhanced dispersive components of surface free energy as compared to Aerosil 200. In addition, these COECH microparticles showed higher amphotericin B loading capacity, enhancement in the in vitro dissolution performance (12-fold) and produces nanoemulsion in the size range of 70-90 nm. Further, the results were in consonance with those observed during ex vivo performance. Thus, the findings revealed simple synthesis of COECH microparticles that showed superior properties of solid substrate for the development of amphotericin B nanoemulsion.


Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A Bernkop-Schnürch, M E Krajicek
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·R SantangeloD S Perlin
Aug 3, 2001·Journal of Colloid and Interface Science·Emil Chibowski, Rafael Perea-Carpio
Mar 5, 2003·International Journal of Pharmaceutics·O KayserS L Croft
Apr 12, 2005·Applied Microbiology and Biotechnology·A LemkeO Kayser
Jul 25, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fude CuiYoshiaki Kawashima
Feb 9, 2007·The AAPS Journal·Brigitta Loretz, Andreas Bernkop-Schnürch
Jun 24, 2009·The Journal of Infectious Diseases·Kishor M WasanSheila J Thornton
Jul 29, 2009·International Journal of Pharmaceutics·Yosra S R ElnaggarOssama Y Abdallah
Oct 22, 2010·Current Microbiology·Amany A El-Sharif, Mohamed H M Hussain
May 12, 2011·AAPS PharmSciTech·Mirna Fernández CerveraJouko Yliruusi
Oct 25, 2011·Colloids and Surfaces. B, Biointerfaces·Nina SchafrothDennis Douroumis
Nov 22, 2011·International Journal of Pharmaceutics·N MohajelK Gilani
Nov 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jun Hyeok KangHan-Gon Choi
Jan 31, 2012·Journal of Materials Science. Materials in Medicine·Kuldeep SinghVikas Rana
Mar 1, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fady IbrahimKishor M Wasan
Aug 1, 2012·Molecular Pharmaceutics·Sanyog JainKaushik Thanki
Dec 29, 2012·International Journal of Biological Macromolecules·Kuldeep SinghVikas Rana
Jul 1, 2012·Carbohydrate Polymers·Riccardo A A MuzzarelliAntonio Gigante

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