Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Eduard PreisUdo Bakowsky

Abstract

Antimicrobial resistance is one of the most serious problems that researchers of multiple disciplines are working on. The number of new antibiotics and their targeted structures have continuously decreased emphasizing the demand of alternative therapy for bacterial infections. Photodynamic therapy is such a promising strategy that has been proven to be effective against a wide range of bacterial strains. In this study, an inhalable nanoformulation for photodynamic therapy against respiratory infections was developed in the form of nano-in-microparticles consisting of curcumin nanoparticles embedded in a mannitol matrix. The produced nano-in-microparticles exhibited suitable aerodynamic properties with a mass median aerodynamic diameter of 2.88 ± 0.13 µm and a high fine particle fraction of 60.99 ± 9.50%. They could be readily redispersed in an aqueous medium producing the original nanoparticles without any substantial changes in their properties. This was confirmed using dynamic light scattering and electron microscopy. Furthermore, the redispersed nanoparticles showed an efficient antibacterial photoactivity causing 99.99992% (6.1log10) and 97.75% (1.6log10) reduction in the viability of Staphylococcus saprophyticus subsp. bov...Continue Reading

Citations

Feb 19, 2020·Expert Review of Anti-infective Therapy·Mahendra RaiCarolina Alves Dos Santos
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Maral Seidi DamyehYasmina Sultanbawa
Feb 16, 2021·Phytotherapy Research : PTR·Bahare SalehiNatália Cruz-Martins
Jan 1, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Partha PalitNima Rezaei
Jun 3, 2021·Pharmaceutics·Kammila Martins Nicolau CostaJoão Augusto Oshiro-Júnior
Jun 17, 2021·Phytotherapy Research : PTR·Khadijeh KhezriAbbas Seyed Zakaryaei
Aug 21, 2021·Journal of Drug Targeting·Morteza RabieiSteven J P McInnes

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