Spread of a single plasmid clone to an untreated individual from a person receiving prolonged tetracycline therapy.

Antimicrobial Agents and Chemotherapy
V PetrocheilouP M Bennett

Abstract

The aerobic gram-negative intestinal flora of two individuals living in close proximity was followed for 17 months. One of these persons was receiving a prolonged tetracycline treatment for acne vulgaris and was colonized by tetracycline-resistant Escherichia coli strains throughout the survey. The other person studied received no antibiotics during the period in question, but was frequently found to excrete a number of E. coli strains harboring tetracycline-resistant plasmids. The two E. coli strains (O75.H7 and O23.H16) excreted from both persons most frequently were indistinguishable, and so were the R-plasmids they carried. This suggests that R-plasmid-carrying E. coli may spread from individuals under treatment to close relatives that have not been treated.

References

Oct 1, 1976·Antimicrobial Agents and Chemotherapy·V PetrocheilouM H Richmond
Apr 2, 1975·Biochimica Et Biophysica Acta·G O HumphreysE S Anderson
Aug 1, 1975·Antimicrobial Agents and Chemotherapy·C L HartleyM H Richmond
Oct 11, 1975·British Medical Journal·C L Hartley, M H Richmond
Jan 25, 1975·Journal of Molecular Biology·M Thomas, R W Davis
May 1, 1972·Journal of Bacteriology·J GrinstedM H Richmond
May 27, 1967·Nature·E Meynell, N Datta
Jul 1, 1963·Journal of Molecular Biology·J H STRAUSS, R L SINSHEIMER

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Citations

Feb 15, 2002·Veterinary Dermatology·C Noli, A Miolo
May 1, 1978·Antimicrobial Agents and Chemotherapy·S T Jørgensen
Aug 1, 1981·The Journal of Applied Bacteriology·T G Mason, G Richardson
Aug 1, 1982·The British Journal of Dermatology·E A EadyW J Cunliffe
Apr 1, 1978·The British Journal of Dermatology·W C Noble, J Naidoo

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