Spread of bla(CTX-M-type) and bla(PER-2) beta-lactamase genes in clinical isolates from Bolivian hospitals

The Journal of Antimicrobial Chemotherapy
Giuseppe CelenzaMariagrazia Perilli

Abstract

To assess the prevalence and types of genes encoding extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. from Bolivia. A total of 642 clinical isolates were collected consecutively during a 4 month period (September to December 2004). Resistance or reduced susceptibility to cefotaxime and/or ceftazidime and/or aztreonam was assessed using double disc synergy tests using clavulanic acid, cefotaxime, ceftazidime and aztreonam to identify putative ESBL-producing isolates. The ESBL determinants were characterized by colony blot hybridization, PCR and DNA sequencing. Of the 642 isolates, 220 (34.3%) showed resistance or reduced susceptibility to cefotaxime and/or ceftazidime and/or aztreonam, and 150 (23.4%) were putative ESBL producers. A total of 106 ESBL-producing isolates contained the bla(CTX-M-2) gene, and 32 isolates had a novel allele, bla(CTX-M-43). bla(CTX-M) alleles were detected in all P. aeruginosa and Acinetobacter spp. studied. In contrast, only 12 ESBL-producing isolates had bla(PER-2), mainly Enterobacteriaceae, although it was also found in a strain of P. aeruginosa. This is the first study on ESBL-producing strains in Bolivia and it re...Continue Reading

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Citations

Oct 17, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Carlos RedondoGuillermina Alonso
Aug 30, 2008·The Journal of Antimicrobial Chemotherapy·Giuseppe CelenzaMariagrazia Perilli
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Pablo PowerGabriel Gutkind
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Federico PerezRobert A Bonomo
Feb 19, 2009·Antimicrobial Agents and Chemotherapy·Renata Cristina PicãoPatrice Nordmann
Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Oct 20, 2011·Critical Reviews in Microbiology·Wei-Hua Zhao, Zhi-Qing Hu
Jun 16, 2012·Critical Reviews in Microbiology·Wei-Hua Zhao, Zhi-Qing Hu
May 21, 2010·Critical Reviews in Microbiology·Wei-Hua Zhao, Zhi-Qing Hu
Nov 21, 2015·Jundishapur Journal of Microbiology·Hasan AfzaliMohammad Zibaei
Jul 24, 2015·BMC Infectious Diseases·Milene Gonçalves QuilesAntonio Carlos Campos Pignatari
Jan 15, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Martina SittováMilan Kolář
Sep 1, 2006·Current Opinion in Microbiology·Rafael Cantón, Teresa M Coque
Apr 1, 2017·Annals of Clinical Microbiology and Antimicrobials·Mahmoud ElhaririSohad M Dorgham
Feb 22, 2018·Antimicrobial Agents and Chemotherapy·Melina RuggieroGabriel Gutkind
Oct 13, 2011·IUBMB Life·Laurent PoirelPatrice Nordmann
Jan 23, 2014·Antimicrobial Agents and Chemotherapy·Lorena Cristina Corrêa FehlbergLibera Maria Dalla-Costa
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Apr 3, 2021·Burns : Journal of the International Society for Burn Injuries·Asma Tchakal-MesbahiLaurence G Rahme
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