PMID: 9664760Jul 17, 1998Paper

Spread of excitation in 3-D models of the anisotropic cardiac tissue. III. Effects of ventricular geometry and fiber structure on the potential distribution

Mathematical Biosciences
P Colli FranzoneB Taccardi

Abstract

In a previous paper we studied the spread of excitation in a simplified model of the left ventricle, affected by fiber structure and obliqueness, curvature of the wall and Purkinje network. In the present paper we investigate the extracellular potential distribution u in the same ventricular model. Given the transmembrane potential v, associated with the spreading excitation, the extracellular potential u is obtained as solution of a linear elliptic equation with the source term related to v. The potential distributions were computed for point stimulations at different intramural depths. The results of the simulations enabled us to identify a number of common features which appears in all the potential patterns irrespective of pacing site. In addition, by splitting the sources into an axial and conormal component, we were able to evaluate the contribution of the classical uniform dipole layer to the total potential field and the role of the superimposed axial component.

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Citations

Dec 14, 2004·Medical & Biological Engineering & Computing·B Hopenfeld
Aug 5, 2005·Annals of Biomedical Engineering·Bruce HopenfeldRob S MacLeod
Feb 10, 2004·Mathematical Biosciences·Piero Colli-FranzoneBruno Taccardi
Mar 11, 2003·Journal of Cardiovascular Electrophysiology·Guanglin LiBin He
Jul 31, 1998·Journal of Cardiovascular Electrophysiology·B TaccardiY Vyhmeister
Oct 16, 2004·Journal of Cardiovascular Electrophysiology·Bruce HopenfeldRob S Macleod
Sep 9, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick A HelmRaimond L Winslow
Apr 11, 2006·IEEE Transactions on Bio-medical Engineering·Robert ModreBernhard Tilg
Mar 23, 2017·Journal of Cardiovascular Electrophysiology·Bryan J CaldwellBruce H Smaill
Nov 16, 2014·American Journal of Physiology. Heart and Circulatory Physiology·David WesternPeter Taggart
May 9, 2002·Physics in Medicine and Biology·Ceon RamonAkira Ishimaru

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