Spread of ictal activity in focal epilepsy

Epilepsia
Katrin Götz-TrabertAndreas Schulze-Bonhage

Abstract

Latencies between seizure onset, propagation of ictal activity, and initial clinical symptoms and signs are critically important for the successful implementation of detection-based intervention systems in the treatment of epilepsy. This study analyzes intracranial EEG-recordings for temporal characteristics of ictal spread and its dependence on focus localization. Intracerebral EEG recordings of 215 seizures from 43 patients with pharmacoresistant focal epilepsy were evaluated based on site of first propagation, latencies between EEG seizure onset, early propagation, and clinical seizure onset. Seizure onset was mesial temporal in 15 patients, neocortical temporal in 15 patients, and frontal in 13 patients. Periods during which ictal activity remained confined to the seizure onset area showed significant differences between the patient groups. Median latencies between electrographic seizure onset and early propagation were significantly longer for patients with mesial temporal (5 s in seizure-based analysis/10 s in patient-based analysis) as compared to neocortical temporal (3 s/5 s) and frontal seizure focus (1 s/2 s; p < 0.01). Concordantly, median latencies to onset of clinical symptomatology were significantly longer for p...Continue Reading

References

Sep 1, 1992·Epilepsia·S S SpencerD D Spencer
Nov 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A Olivier
Apr 1, 1996·Epilepsia·J S Ebersole, S V Pacia
Jan 22, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yuko Mizuno-MatsumotoRonald P Lesser
Jan 26, 2005·Annals of Neurology·Ivan OsorioSteven B Wilkinson
Aug 30, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sukhi Grewal, Jean Gotman
Oct 6, 2005·Stereotactic and Functional Neurosurgery·Kostas N FountasPatrick D Jenkins
Dec 1, 2005·Brain : a Journal of Neurology·Susanne Fauser, Andreas Schulze-Bonhage
Feb 26, 2008·Epilepsy Research·Claus Henning LäppchenAndreas Schulze-Bonhage

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Citations

Jul 17, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Cayetano E Napolitano, Miguel A Orriols
Jun 2, 2011·Epilepsia·Jan RémiSoheyl Noachtar
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Izumi ToyodaPaul S Buckmaster
Oct 30, 2010·Epilepsy & Behavior : E&B·Ivan Osorio, M Frei
Jun 10, 2009·Human Brain Mapping·Louise TyvaertJean Gotman
May 30, 2015·International Journal of Neural Systems·Cristian DonosAndreas Schulze-Bonhage
Jan 24, 2012·NeuroImage·Helmut Laufs
Jan 29, 2013·Journal of Neuroscience Methods·Christoph FlammManfred Deistler
Oct 13, 2014·Epilepsy Research·Pue Farooque, Robert Duckrow
May 19, 2017·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ariel LevyDang Khoa Nguyen
Aug 11, 2017·Nature Communications·L Federico RossiMatteo Carandini
May 19, 2020·Clinical EEG and Neuroscience·Jan RémiIngo Borggraefe
Jan 13, 2018·Epilepsia·Cristian DonosAndreas Schulze-Bonhage
May 6, 2021·Annals of Clinical and Translational Neurology·Abdullah AzeemJean Gotman

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