Spread of infection, in an animal model, after intramedullary nailing of an infected external fixator pin track

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
J C ClasperP E Watkins

Abstract

Implant sepsis. due to previous external fixator pin track infection, is the most common complication of secondary intramedullary (IM) nailing of the tibia. We have developed an animal model, which allows different treatment methods to be studied. Using an established ovine model of a pin track infection, Staphylococcus aureus was used to infect the external fixator pins, two weeks prior to reamed IM nailing. In the control group, the animals were killed at a mean of 10.5 days following nailing, when widespread infection was evident, with septic arthritis, abscess formation, and infection of the entire length of the tibia in all six animals. In the treatment group, before IM nailing, the pin sites were debrided, and both local and systemic antibiotics were administered. All surgical wounds healed without evidence of infection, 4 of the 6 animals survived for 28 days, and bacteria were only isolated from 1 of the 6 implants. Treatment was successful at reducing, but not eliminating, infection after secondary nailing.

References

Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P J RespetB P Meinhard
Nov 1, 1996·Clinical Orthopaedics and Related Research·R MartinB Smyth
May 1, 1997·The Journal of Bone and Joint Surgery. British Volume·P Antich-AdroverC Puente-Alonso
Aug 13, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Y H An, R J Friedman
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J C ClasperP E Watkins

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Citations

Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P F HillP E Watkins
May 31, 2013·Journal of the Royal Army Medical Corps·William G P EardleyJ C Clasper
May 25, 2012·Journal of Biomedical Materials Research. Part a·K D SinclairR D Bloebaum
Apr 11, 2017·International Journal of Antimicrobial Agents·Jinlong ShaoX Frank Walboomers
Feb 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Kuo-An LaiMeng-Yi Chen
May 2, 2006·Journal of Orthopaedic Trauma·Paul J HarwoodHans-Christoph Pape
Jan 2, 2010·The Journal of Bone and Joint Surgery. British Volume·F E BilenH I Balci
Aug 16, 2005·Journal of the Royal Army Medical Corps·J C Clasper, S L Phillips
Sep 12, 2008·The Journal of Trauma·Khaled M Emara, Mohamed Farouk Allam
Mar 14, 2019·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Irene I López-TorresJavier Vaquero-Martín
Jul 30, 2017·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·S A DingemansT Schepers
Jun 18, 2003·Journal of Orthopaedic Surgery·C C Wu

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