PMID: 518303Jan 1, 1979Paper

Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits

Archives of Virology
H KreyR Rott

Abstract

Selective damage of the optic nerve of 14 rabbits without interfering with the choroidal blood flow which supplies the retina and without altering the autonomic nerve supply was successfully achieved by Xenon coagulation. This procedure interrupted the axonal pathway between the brain and the eye. After experimental infection with Borna disease virus the typical disease could be induced. The pathognomonic retinopathy as well as characteristic perivascular choroidal infiltrates, however, did not appear in eyes with coagulated nerve heads. In general virus-specific antigen or infectious virus were not present in the retinas of such damaged eyes. These results permit the conclusion that the ocular expression of Borna disease is a consequence of virus transport via the optic nerve.

References

Jan 1, 1977·Survey of Ophthalmology·J D Fratkin, A G Smith
Feb 1, 1979·American Journal of Ophthalmology·H F KreyC B Boschek
Jan 1, 1977·Archives of Virology·H LudwigR Rott
Apr 1, 1967·Archives of Ophthalmology·A E Krill
Jul 1, 1964·Archives of Ophthalmology·M E SMITH

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Citations

Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·H KreyM Gierend
Jan 1, 1991·Archives of Virology·R RottK Frese
Apr 2, 2003·Journal of Neuroimmunology·Tobias StahlJohannes Seeger
Jun 1, 1993·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·S Sasaki, H Ludwig
May 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R Dürrwald, H Ludwig
Nov 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·R RottL Stitz
Sep 6, 2008·APMIS. Supplementum·Hauke Krey
Feb 1, 2014·The Veterinary Journal·Jonas Johansson WensmanMikael Berg
Jan 9, 2001·The Veterinary Journal·J A Richt, R Rott
May 24, 2016·Animal Health Research Reviews·Ian TizardSusan Payne
Jul 11, 1998·The Journal of Laryngology and Otology·P V LimJ Oates
Feb 6, 2017·Animal Health Research Reviews·Ian TizardSusan Payne
Mar 2, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Mar 10, 2001·Reviews in Medical Virology·I Jordan, W I Lipkin

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