Spreading depression activates unfolded protein response

Neuroscience Letters
Edda SchneelochWulf Paschen

Abstract

Preconditioning is a process where a preceding non-lethal form of stress activates a stress response that protects cells against an otherwise lethal form of stress. Preconditioning can be induced in various ways including short-term ischemia or spreading depression. Here we investigated the effect of 1 h repetitive spreading depression on the unfolded protein response (UPR), a stress response activated under conditions associated with endoplasmic reticulum (ER) dysfunction. Spreading depression induced processing of xbp1 mRNA, indicative of an activation of UPR. Processing of xbp1 was paralleled by a rise in grp78 mRNA levels resulting from an activation of a signal transduction pathway that depends on protein synthesis. Preconditioning-induced activation of UPR may preserve ER functioning under pathological conditions interfering with ER functions.

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Citations

May 1, 2007·Antioxidants & Redox Signaling·Satoshi OgawaOsamu Hori
Aug 26, 2009·Journal of Gastroenterology and Hepatology·Umbreen AhmedPhillip S Oates
Jul 6, 2019·Frontiers in Neuroscience·Audrey M ThiebautBenoit D Roussel
Jan 27, 2017·Neural Regeneration Research·Ping-Ping ShenJia-Chun Feng

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