Spreading Depression and Seizure Unification Experimentally Observed in Epilepsy

BioRxiv : the Preprint Server for Biology
Fatemeh BahariBruce J Gluckman


Recurrent spontaneous seizures have been considered the sine qua non of epilepsy. Epileptic seizures were first associated with intense electrical activity measured from the brain in 1933 1. Spreading depression of brain activity was discovered by Leao in 1944 2, and has since been shown associated with migraine, stroke and traumatic brain injury 3,4. Although for many years spreading depression was thought to have only rare genetic links to epilepsy 5, recently it has been proposed that seizure-triggered spreading depression could underlie sudden unexplained death in epilepsy (SUDEP) 6. The physiological underpinning of spreading depression is an electrical spreading depolarization (SD) of brain cells. The depolarization is associated with a large, prolonged negative shift in tissue potential that cannot be well detected with standard human electroencephalographic (EEG) technology. Nevertheless, in recent years, computational models of the dynamics of neuron biophysics have shown a linkage between seizures and SD 7, and have predicted the possibility of dynamic trajectories linking the two phenomena 8. We developed a recording system for chronic, long-term measurements that provides a view of the complex interactions between s...Continue Reading

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