Spreading depression enhances the spontaneous epileptiform activity in human neocortical tissues

The European Journal of Neuroscience
Ali Gorji, Erwin-Josef Speckmann

Abstract

Spreading depression (SD) is a well-known phenomenon in animal models of experimental epilepsy. However, the interaction of SD with epileptiform activity in human neuronal tissues is not clear. The aim of the present study was to investigate the effect of SD on synchronous rhythmic sharp field potentials in human neocortical slices. Spreading depression was elicited in human neocortical slices that exhibited sharp potentials. Extracellular field potentials were recorded from the third and fifth layers. SD significantly enhanced the repetition rate and amplitude of spontaneous rhythmic potentials in all tested slices. The results indicate that SD may facilitate the synchronization of different foci of rhythmic sharp field potentials and increase the excitability in human brain tissue.

References

Jul 2, 1998·Brain : a Journal of Neurology·R KöhlingF Oppel
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·N HadjikhaniM A Moskowitz
Jun 30, 2001·Brain Research·A GorjiE J Speckmann
Dec 26, 2001·Brain Research. Brain Research Reviews·A Gorji
Dec 4, 2002·Epilepsia·Ali GorjiErwin-Joseph Speckmann
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Anthony J StrongMartin Lauritzen
Jul 1, 1953·Journal of Neurophysiology·A VAN HARREVELD, J S STAMM
Aug 1, 1955·Electroencephalography and Clinical Neurophysiology·A VAN HARREVELD, J S STAMM
Jan 31, 2004·Neurobiology of Disease·A GorjiE-J Speckmann

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Citations

Sep 24, 2005·Anatomy and Embryology·A GorjiE-J Speckmann
Jun 27, 2013·Current Pain and Headache Reports·P R BauerG H Visser
Nov 29, 2011·Brain : a Journal of Neurology·Jens P DreierUNKNOWN COSBID study group
Oct 16, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Daniel R KramerCharles Y Liu
Jul 7, 2009·Experimental Neurology·Ana Paula Barbosa do AmaralRubem Carlos Araújo Guedes
Jul 16, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Martin FabriciusMartin Lauritzen
Jan 8, 2008·Journal of Theoretical Biology·M A DahlemE Schöll
Mar 24, 2006·The European Journal of Neuroscience·Brigitta WernsmannAli Gorji
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Ricardo Abadie-GuedesRanilson S Bezerra
Aug 27, 2014·Annals of Neurology·Jed A HartingsNorberto Andaluz
Jun 7, 2006·Journal of Neuroscience Methods·Rüdiger Köhling, Massimo Avoli
Dec 26, 2013·Experimental Neurology·Marius EickhoffAli Gorji
Feb 15, 2015·Neuroscience Letters·Thays Kallyne Marinho de SouzaRubem Carlos Araújo Guedes
May 25, 2016·Current Pain and Headache Reports·Shih-Pin Chen, Cenk Ayata
Dec 18, 2013·Seizure : the Journal of the British Epilepsy Association·Xiang-qing WangSheng-yuan Yu
Jan 7, 2017·Cephalalgia : an International Journal of Headache·P PronteraC Costa
Sep 24, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jed A HartingsMichael L Rolli
Dec 21, 2005·Brain : a Journal of Neurology·Martin FabriciusMartin Lauritzen
May 7, 2008·Expert Review of Neurotherapeutics·Justin M SmithChristopher L-H Huang
Sep 2, 2008·Expert Review of Neurotherapeutics·Joost HaanMichel D Ferrari
Mar 6, 2009·Journal of Neurophysiology·Frank FunkeMichael Müller
Oct 13, 2020·The Journal of Clinical Investigation·Punam A Sawant-PokamK C Brennan
Nov 10, 2020·Cephalalgia : an International Journal of Headache·Lyudmila V VinogradovaTatiana M Medvedeva
Jan 19, 2021·Epilepsy & Behavior : E&B·Mohamed AlKhajaTariq Abalkhail
Nov 6, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Zoya J R BastanyAli Gorji
Jul 28, 2021·Nature Reviews. Neurology·Prisca R BauerJosemir W Sander

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