Spreading depression induces c-fos-like immunoreactivity and NGF mRNA in the rat cerebral cortex

Brain Research
D G HerreraA C Cuello

Abstract

Application of potassium chloride (KCl) to the brain surface elicits spreading depression which leads to a marked induction of the proto-oncogene c-fos in the treated cerebral cortex at the earliest time examined (90 min). High levels of c-fos immunoreactivity are observed up to 6 h after KCl treatment. The areas affected include the cingulate, entorhinal and frontoparietal cortex throughout the treated hemisphere. The c-fos expression preceded an increase in both NGFmRNA and NGF-like protein(s). A maximal increase in c-fos was detected within 3 h, whereas NGFmRNA peaked at 12 h and NGF-like protein(s) reached their maximum level 24 h after KCl application. The most prominent increase in NGFmRNA was measured in the entorhinal cortex (50-fold), but other cortical areas also showed a moderate increase of 2-3-fold. In conclusion, our results provide evidence that increases in c-fos and NGF expression are early adaptive responses following brain injury.

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Citations

Oct 1, 1996·Progress in Neurobiology·D G Herrera, H A Robertson
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsushimaA M Hakim
Jul 1, 1994·Reviews in the Neurosciences·S A Scott, K A Crutcher
Jul 1, 1997·Reviews in the Neurosciences·M S Kelley, O Steward
Sep 24, 2011·Cephalalgia : an International Journal of Headache·Geoffrey A LambertAlessandro S Zagami
Jan 1, 1995·Cephalalgia : an International Journal of Headache·M Sandler
Jan 6, 2001·Journal of Neurosurgical Anesthesiology·Y KitaharaK Shimoji
Jun 27, 1998·Current Opinion in Neurology·A A Parsons
Dec 1, 1998·CNS Drug Reviews·Frank S MennitiBertrand L Chenard

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