PMID: 9555973Apr 29, 1998Paper

Spreading depression induces depletion of MAP2 in area CA3 of the hippocampus in a rat unilateral carotid artery occlusion model

Journal of Neurotrauma
T IijimaH Sankawa

Abstract

Traumatic brain injury (TBI) induces neuronal cell loss in area CA3 of the hippocampus. However, it has not yet been established why traumatic injury of the cortex induces neuronal damage in more remote areas. Spreading depression (SD) may be one potential mechanism for this pathophysiology. The present study evaluated whether SD on the cortex evokes a pathological change in the hippocampus. Forty-two Fisher rats were assigned to four groups: Group I: sham operation (n = 7), Group II: right carotid occlusion (UO) for 7 days (n = 7), Group III: repeated induction of SD by KCl application on dura for 7 days (n = 7), Group III' for 3 h (n = 7), Group IV: SD induction and UO for 7 days (n = 14) Group IV' for 3 h (n = 7). In 5 out of 7 animals in Groups III' and IV', cerebral blood flow (CBF) was monitored using laser Doppler flowmetry for 3 h during the passage of SD. The brains were processed for immunohistochemical analysis of microtubule-associated protein 2 (MAP2). Reactive hyperemia induced by SD was not significantly suppressed by right carotid occlusion (194 +/- 25% and 181 +/- 42% UO in Groups III and IV, respectively). In 6 out of 7 animals in a 7-day model of Group IV, and 3 animals in a 7-day model of Group III, MAP2 dep...Continue Reading

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Citations

Oct 30, 2003·Drug and Chemical Toxicology·Guy LallementFrédéric Dorandeu
Feb 11, 2000·Annals of the New York Academy of Sciences·W S Carbonell, M S Grady
Jan 24, 2012·Experimental Neurology·Xiao-Xin YanPeter R Patrylo
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·W A LaMarrP C Dedon

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