Sprifermin treatment enhances cartilage integration in an in vitro repair model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Mackenzie L SennettGeorge R Dodge

Abstract

Cartilage integration remains a clinical challenge for treatment of focal articular defects. Cartilage exhibits limited healing capacity that declines with tissue maturation. Many approaches have been investigated for their ability to stimulate healing of mature cartilage or integration of repair tissue or tissue-engineered constructs with native cartilage. Growth factors present in immature tissue may enhance chondrogenesis and promote integrative repair of cartilage defects. In this study, we assessed the role of one such factor, fibroblast growth factor 18 (FGF18). Studies using FGF18 have shown a variety of positive effects on cartilage, including stimulation of chondrocyte proliferation, matrix biosynthesis, and suppression of proteinase activity. To explore the role of FGF18 on cartilage defect repair, we hypothesized that treatment with recombinant human FGF18 (sprifermin) would increase matrix synthesis in a defect model, thus improving integration strength. To test this hypothesis, 6 mm cartilage cylinders were harvested from juvenile bovine knees. A central 3 mm defect was created in each explant, and this core was removed and replaced. Resulting constructs were cultured in control or sprifermin-containing medium (wee...Continue Reading

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Dec 28, 2018·Journal of Biomaterials Science. Polymer Edition·Patrick E DonnellySuzanne A Maher
Aug 19, 2020·Nature Reviews. Rheumatology·Yangli XieMoosa Mohammadi
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May 3, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Honey HendesiGeorge R Dodge
Aug 25, 2021·Expert Opinion on Investigational Drugs·Jia LiChanghai Ding

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