Abstract
To investigate sprint-training effects on muscle metabolism during exercise in subjects with (type 1 diabetic group) and without (control group) type 1 diabetes. Eight subjects with type 1 diabetes and seven control subjects, matched for age, BMI, and maximum oxygen uptake (Vo(2peak)), undertook 7 weeks of sprint training. Pretraining, subjects cycled to exhaustion at 130% Vo(2peak). Posttraining subjects performed an identical test. Vastus lateralis biopsies at rest and immediately after exercise were assayed for metabolites, high-energy phosphates, and enzymes. Arterialized venous blood drawn at rest and after exercise was analyzed for lactate and [H(+)]. Respiratory measures were obtained on separate days during identical tests and during submaximal tests before and after training. Pretraining, maximal resting activities of hexokinase, citrate synthase, and pyruvate dehydrogenase did not differ between groups. Muscle lactate accumulation with exercise was higher in type 1 diabetic than nondiabetic subjects and corresponded to indexes of glycemia (A1C, fasting plasma glucose); however, glycogenolytic and glycolytic rates were similar. Posttraining, at rest, hexokinase activity increased in type 1 diabetic subjects; in both gr...Continue Reading
References
Aug 15, 1976·The Biochemical Journal·M BergerN B Ruderman
Oct 1, 1986·Diabetologia·Y T KruszynskaK G Alberti
Jul 24, 1986·The New England Journal of Medicine·H Yki-Järvinen, V A Koivisto
Apr 1, 1986·Journal of Applied Physiology·N McCartneyN L Jones
Nov 1, 1971·The Biochemical Journal·H G CooreP J Randle
Sep 1, 1995·The American Journal of Physiology·C T PutmanG J Heigenhauser
Apr 1, 1994·Journal of Applied Physiology·C G StathisR J Snow
Jul 1, 1997·Journal of Applied Physiology·J A Simoneau, D E Kelley
Jun 15, 1997·The Journal of Physiology·M J McKennaN L Jones
Jun 11, 1998·Journal of Applied Physiology·J D MacDougallK M Smith
Jul 27, 1999·Metabolism: Clinical and Experimental·N NakaiY Shimomura
Jul 25, 2000·Diabetes·D E Kelley, L J Mandarino
Jul 25, 2000·Diabetes·M J HolnessM C Sugden
Oct 29, 2000·Journal of Applied Physiology·A R HarmerD M Eager
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Cheol S ChoiJang H Youn
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Gregory J CrowtherKevin E Conley
Jan 16, 2004·The Journal of Physiology·Carsten JuelFlemming Dela
May 8, 2004·Metabolism: Clinical and Experimental·Petr WohlTerezie Pelikánová
Nov 3, 2004·Journal of Science and Medicine in Sport·C BarnettD Jenkins
Sep 24, 2005·Journal of Applied Physiology·Alison R HarmerJeff R Flack
Jul 11, 2006·The Journal of Physiology·Martin J GibalaMark A Tarnopolsky
Feb 28, 2007·Diabetes Care·Alison R HarmerJeff R Flack
Nov 10, 2007·The Journal of Physiology·Kirsten A BurgomasterMartin J Gibala
Citations
Jan 12, 2011·Wiener medizinische Wochenschrift·Patrick WahlJoachim Mester
Nov 30, 2010·Journal of Obesity·Stephen H Boutcher
Nov 9, 2012·Sports Medicine·Cajsa TonoliRomain Meeusen
Oct 17, 2013·Sports Medicine·Nicholas H GistKirk J Cureton
Dec 20, 2012·ISRN Endocrinology·Lisa Stehno-Bittel
Dec 4, 2013·The Journal of Physiology·A R HarmerJ R Flack
Dec 11, 2013·Canadian Journal of Diabetes·Jane YardleyJonathan McGavock
May 1, 2009·Diabetes/metabolism Research and Reviews
Feb 16, 2011·Journal of Clinical Nursing·Ching-Hsiang WongChi-Wen Chang
Sep 24, 2010·Pediatric Diabetes·Matthew P KrauseThomas J Hawke
Jul 31, 2013·Scandinavian Journal of Medicine & Science in Sports·M SlothU Dalgas
Apr 21, 2010·Clinical Science·Sanjoy GhoshIsmail Laher
Mar 19, 2009·Orvosi hetilap·Péter Apor
Jan 28, 2017·The Lancet. Diabetes & Endocrinology·Michael C RiddellLori M Laffel
Mar 30, 2018·Journal of Applied Physiology·Jonathon SenefeldSandra K Hunter
Oct 4, 2018·The Journal of Clinical Endocrinology and Metabolism·Sam N ScottSam O Shepherd
Apr 15, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Flurin ItemMarco Toigo
Jul 1, 2017·Current Opinion in Neurology·Cynthia M F MonacoThomas J Hawke
Oct 23, 2019·Diabetes Care·Elsa HeymanSémah Tagougui
Sep 11, 2012·The Journal of Clinical Endocrinology and Metabolism·A J FaheyP A Fournier
Jun 24, 2018·Sports Medicine·Cesare GranataDavid J Bishop
Aug 21, 2019·Frontiers in Endocrinology·Olivia McCarthyRichard M Bracken
Apr 1, 2020·European Journal of Preventive Cardiology·Marco AmbrosettiAnn-Dorthe Olsen Zwisler
Apr 25, 2020·International Journal of Molecular Sciences·Antonio CrisafulliClaudia Penna
Mar 16, 2017·Acta Diabetologica·Roberto CodellaLivio Luzi
Jun 15, 2017·Diabetes Technology & Therapeutics·Dessi ZaharievaMichael C Riddell
Dec 14, 2018·Frontiers in Endocrinology·Jane E YardleyRichard M Bracken
Feb 22, 2021·European Journal of Preventive Cardiology·Marco AmbrosettiAnn-Dorthe Olsen Zwisler
Jul 6, 2020·Diabetes Research and Clinical Practice·Roberta AssaloniMatteo Vandoni
Aug 27, 2021·The British Journal of Nutrition·Mahzad SanayeiAli Barzegar