PMID: 6969296Jun 1, 1980Paper

Sprouting and regression of the nerve at the frog neuromuscular junction in normal conditions and after prolonged paralysis with curare

Journal of Neurocytology
A WernigH Stöver

Abstract

A light microscopical, histochemical and electron microscopical investigation of the frog neuromuscular junction has been performed on muscles from animals in different functional states of activity. The combined staining of axon terminals and cholinesterase (ChE) allows a precise description of the nerve terminal arborization and its synaptic contacts. Most terminal arborizations form long continuous contacts with the muscle cell. Distinquishable from these are nerve branches (usually of small diameter)d or distal endings of branches with one or several small and isolated contacts. It is assumed that these are sprouts with newly-formed synaptic sites. Other sprouts end without apparent synaptic contact. At the uttrastructural levet, nerve sprouts end without apparent synaptic contact. At the uttrastructural levet, nerve sprouts growing into empty, well-differentiated synaptic gutters or inducing the formation of new synaptic sites were observed. In other sites, ChE is apparently located at postsynaptic gutters with no nerve present. Similarly, in the electron microscope, well-differentiated synaptic gutters lacking any nerve or Schwann cell elements were observed. In addition, synaptic gutters only partially occupied by the ne...Continue Reading

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Citations

May 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·E N BezginaA L Zefirov
Feb 1, 1985·Journal of Neurocytology·A A Herrera, D R Scott
Dec 1, 1989·Journal of Neurocytology·A P Anzil, A Wernig
Nov 1, 1991·Journal of Neurocytology·A WernigA Irintchev
Oct 1, 1994·Journal of Neurocytology·B Langenfeld-OsterA Wernig
Dec 1, 1985·Journal of Neurocytology·M R BennettN A Lavidis
Aug 1, 1982·Journal of Neurocytology·M A Fahim, N Robbins
Jan 14, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Nicholas J HudsonCraig E Franklin
Mar 8, 2012·Molecular Neurobiology·Jeffrey S DasonAlberto Ferrús
Mar 1, 1990·Journal of the Neurological Sciences·J H WokkeG J Leppink
Aug 1, 1985·Brain Research·J PearceD E Meiss
Sep 1, 1990·Neurobiology of Aging·W B Alshuaib, M A Fahim
Mar 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·G A Lnenicka
Jan 1, 1986·Progress in Neurobiology·A Wernig, A A Herrera
May 6, 1981·Neuroscience Letters·A WernigU Schwarz
Jan 16, 1989·Neuroscience Letters·J DiazM Pécot-Dechavassine

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