Sprouting of corticospinal tract axons from the contralateral hemisphere into the denervated side of the spinal cord is associated with functional recovery in adult rat after traumatic brain injury and erythropoietin treatment.

Brain Research
Yanlu ZhangMichael Chopp

Abstract

Erythropoietin (EPO) promotes functional recovery after traumatic brain injury (TBI). This study was designed to investigate whether EPO treatment promotes contralateral corticospinal tract (CST) plasticity in the spinal cord in rats after TBI. Biotinylated dextran amine (BDA) was injected into the right sensorimotor cortex to anterogradely label the CST. TBI was induced by controlled cortical impact over the left parietal cortex immediately after BDA injections. EPO (5000 U/kg) or saline was administered intraperitoneally at Days 1, 2, and 3 post-injury. Neurological function was assessed using a modified neurological severity score (mNSS) and footfault tests. Animals were sacrificed 35 days after injury and brain sections stained for histological analysis. Compared to the saline treatment, EPO treatment significantly improved sensorimotor functional outcome (lower mNSS and reduced footfaults) from Days 7 to 35 post-injury. TBI alone significantly stimulated contralateral CST axon sprouting toward the denervated gray matter of the cervical and lumbar spinal cord; however, EPO treatment further significantly increased the axon sprouting in TBI rats although EPO treatment did not significantly affect axon sprouting in sham anima...Continue Reading

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Citations

Sep 7, 2012·Journal of Neurotrauma·Andrew GardnerDerek K Jones
Apr 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erica A DaleGordon S Mitchell
Feb 8, 2014·Brain Research·Shlomit DachirEsther Shohami
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Jan 8, 2016·Brain Research·Sarah HellewellMaria Cristina Morganti-Kossmann
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Oct 12, 2012·Annals of the New York Academy of Sciences·Ye XiongMichael Chopp
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Dec 4, 2020·Neural Regeneration Research·Hajime Takase, Robert W Regenhardt

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