PMID: 6405976Mar 28, 1983Paper

Sprouting of sympathetic fibers in the hippocampus in the absence of major target cell candidates

Brain Research
G M Peterson, R Loy

Abstract

Noradrenergic fibers of sympathetic origin enter the hippocampal formation following removal of the cholinergic septal afferents. These sympathetic fibers apparently form synaptic contacts with cells in the hippocampus, but the identity of the postsynaptic cell is unknown. As the two major cell types of the hippocampal formation are the pyramidal cells and the dentate granule cells, we sought to determine how their absence would affect the ingrowth and distribution of the sympathetic fibers following septal lesions. Hippocampal pyramidal cells were selectively removed with kainic acid and granule cells were selectively removed with colchicine 4 days before lesions were placed in the medial septal-diagonal band nuclear complex. Animals were sacrificed 4-5 weeks after the septal lesions and the brains prepared for catecholamine fluorescence histochemistry. Sympathetic fibers innervate the hippocampal formation of brains depleted of pyramidal cells or granule cells. Thus, it appears that neither cell type is an obligatory postsynaptic target or is necessary for the ingrowth of sympathetic fibers. The anomalous sympathetic fibers may be contacting interneurons or glia.

References

Jan 1, 1978·Annual Review of Neuroscience·S S Varon, R P Bunge
Sep 1, 1976·Experimental Neurology·P Coyle
Nov 15, 1973·The Journal of Comparative Neurology·S MoskoC W Cotman
Oct 1, 1980·Journal of Neuroscience Methods·J C De la Torre
Feb 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L C SchmuedP E Sawchenko
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R B Goldschmidt, O Steward
Feb 1, 1982·Experimental Neurology·K A Crutcher, J N Davis
Feb 15, 1980·The Journal of Comparative Neurology·R LoyR Y Moore

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Citations

Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C G Choi, J Frahm
Apr 29, 2010·Current Psychiatry Reports·Manuel F Casanova
May 1, 1991·The Journal of Comparative Neurology·M Caeser, A Aertsen

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