Sprouting of the visual corticocollicular terminal field after removal of contralateral retinal inputs in neonatal rabbits

Experimental Brain Research
G García del CañoL Martínez-Millán

Abstract

The morphological changes occurring in the visual corticocollicular projection following removal of the contralateral retina (within the first 48 h of postnatal life) were studied using New Zealand rabbits. At 45-50 days after lesion, the corticocollicular terminal field was examined by anterograde transport of Phaseolus vulgaris leucoagglutinin, which was applied iontophoretically in the central region of the contralateral striate cortex. In contrast to normal intact rabbits of the same age, the corticocollicular terminal field was markedly enlarged in experimental animals. In the centre of the field we found abundant oblique fibres which sent out branches. These collateral fibres coursed over long distances, parallel to the pial surface, in the stratum zonale and in the upper part of the stratum griseum superficiale. The presence of these fibres, together with an increased density of synaptic boutons at more superficial levels of the sprouted terminal field, suggest that corticocollicular fibres tended to occupy territories left vacant when retinocollicular axons degenerated after enucleation. The high density and extensive distribution of these corticocollicular fibres may be due to the continued growth of the fibres, which ...Continue Reading

Citations

Jul 13, 2002·Brain Research. Brain Research Protocols·Inmaculada GerrikagoitiaLuis Martínez-Millán
Nov 26, 2009·Neuroscience·I C Mundiñano, L Martínez-Millán
Jun 5, 2016·Hearing Research·Alexandria M H Lesicko, Daniel A Llano
Nov 17, 2005·Nature Reviews. Neuroscience·Giorgio M Innocenti, David J Price

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