Spry1 and spry2 are essential for development of the temporomandibular joint.

Journal of Dental Research
Patricia PurcellOphir D Klein

Abstract

The temporomandibular joint (TMJ) is a specialized synovial joint essential for the function of the mammalian jaw. The main components of the TMJ are the mandibular condyle, the glenoid fossa of the temporal bone, and a fibrocartilagenous disc interposed between them. The genetic program for the development of the TMJ remains poorly understood. Here we show the crucial role of sprouty (Spry) genes in TMJ development. Sprouty genes encode intracellular inhibitors of receptor tyrosine kinase (RTK) signaling pathways, including those triggered by fibroblast growth factors (Fgfs). Using in situ hybridization, we show that Spry1 and Spry2 are highly expressed in muscles attached to the TMJ, including the lateral pterygoid and temporalis muscles. The combined inactivation of Spry1 and Spry2 results in overgrowth of these muscles, which disrupts normal development of the glenoid fossa. Remarkably, condyle and disc formation are not affected in these mutants, demonstrating that the glenoid fossa is not required for development of these structures. Our findings demonstrate the importance of regulated RTK signaling during TMJ development and suggest multiple skeletal origins for the fossa. Notably, our work provides the evidence that the...Continue Reading

References

Mar 1, 1992·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·G H Sperber
Apr 1, 1972·The Anatomical Record·M Silbermann, J Frommer
Mar 21, 2000·Genesis : the Journal of Genetics and Development·D A OvchinnikovR R Behringer
Oct 8, 2004·The International Journal of Developmental Biology·Fei LiuBarbara E Kream
Feb 5, 2005·Developmental Cell·M Albert BassonJonathan D Licht
Aug 1, 2006·Biochimica Et Biophysica Acta·Anne-Sophie ArmandChristophe Chanoine
Dec 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoshihiro ShibukawaEiki Koyama
Jun 8, 2007·Orthodontics & Craniofacial Research·Mina MinaD A Velonis
Jun 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L Henry GoodnoughJill A Helms
Aug 19, 2007·Mechanisms of Development·Ian C WelshTimothy P O'Brien
Jun 3, 2008·Mechanisms of Development·Shuping GuYiPing Chen
Aug 6, 2008·Developmental Biology·B McBratney-OwenG M Morriss-Kay
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Patricia PurcellClifford J Tabin
Mar 5, 2010·Journal of Dental Research·T OchiaiE Koyama
May 13, 2010·BMC Developmental Biology·Xuehui YangRobert Friesel
Oct 14, 2010·Journal of Biochemistry·Nobuyuki Itoh, David M Ornitz
Oct 28, 2010·Development·Karel Dorey, Enrique Amaya
Jan 5, 2011·Biochemical and Biophysical Research Communications·Kaori MatsumuraSeiji Nakamura
Jan 1, 2010·Critical Reviews in Eukaryotic Gene Expression·Nan E Hatch
Sep 29, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ying WangYiPing Chen

❮ Previous
Next ❯

Citations

May 25, 2012·Journal of Dental Research·T YasudaE Koyama
Apr 20, 2014·Cancer Metastasis Reviews·Samar Masoumi-MoghaddamDavid Lawson Morris
Nov 14, 2012·Molecular Genetics and Metabolism·Hyun-Seok JinSeon-Yong Jeong
Mar 29, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert J Hinton
Sep 5, 2014·PloS One·Adele HillPatricia Purcell
Mar 3, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Julia C Boughner
Jul 20, 2019·Development·Ryan R RobertsAmy E Merrill
Feb 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela RuscittoMildred C Embree
May 20, 2020·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·W Eugene Roberts, Charles J Goodacre
Mar 11, 2017·G3 : Genes - Genomes - Genetics·Christopher J PercivalBenedikt Hallgrímsson
Feb 19, 2015·The Journal of Craniofacial Surgery·Jiewen DaiSteve Guofang Shen

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE17473

Software Mentioned

Dolphin Imaging
Adobe Photoshop
Dolphin

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.