Spuriously low plasma propranolol concentrations resulting from blood collection methods.

Clinical Pharmacology and Therapeutics
R H Cotham, D G Shand

Abstract

Spuriously low values of plasma propranolol concentrations resulted when one commercial brand of collection tube was used. The mechanism of this effect was established and was due to the presence of the stopper containing substances that reduced plasma propranolol binding and resulted in a redistribution of the drug in whole blood so that more was present in the cells and less in the plasma. A similar phenomenon was noted some years ago when a needle for intravenous infusion was used as an indwelling cannula. Th mechanism in this case could not be established as in the interim the phenomenon was no longer detectable. Although it was established that these findings do not apply to all drugs, the data suggest that collection methods should be routinely checked at intervals unless separate venipuncture and all glass collection tubes are used.

Citations

Jan 1, 1976·European Journal of Clinical Pharmacology·D FremstadP K Lunde
Nov 1, 1977·Journal of Clinical Pharmacology·H B HuckerB W Lei
Jan 1, 1976·Acta Pharmacologica Et Toxicologica·D Fremstad, K Bergerud
Jan 1, 1980·Journal of Immunoassay·S R Lader
Jan 1, 1983·Drug Metabolism Reviews·G R Wilkinson
Mar 1, 1979·The New England Journal of Medicine
Nov 1, 1979·European Journal of Clinical Pharmacology·A MelanderE Wåhlin-Boll
Aug 1, 1979·British Journal of Clinical Pharmacology·L WongP K Mehta
Nov 1, 1986·British Journal of Clinical Pharmacology·P A Routledge
May 1, 1987·Drug Intelligence & Clinical Pharmacy·S C SorrellsJ A Pieper
Sep 1, 1984·British Journal of Clinical Pharmacology·D M HibbardD B Hunninghake
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·L BorgströmR Lenander
Dec 1, 1978·The Journal of Pharmacy and Pharmacology·E A TaylorP Turner
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·P DayerJ Fabre
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P VilleneuveD Marleau
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·J HasegawaL Z Benet
Jun 21, 1979·Psychopharmacology·D S RobinsonK R Lamborn
Jan 1, 1982·Biopharmaceutics & Drug Disposition·M KramlJ Mullane
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·W A WarginM L Rylander
Dec 16, 1983·Pharmaceutisch Weekblad. Scientific Edition·R JanknegtF W Merkus
Dec 1, 1976·The Journal of Pharmacy and Pharmacology·M T Rosseel, M G Bogaert
Mar 1, 1979·British Journal of Clinical Pharmacology·G L JenningsP I Korner
Oct 1, 1985·British Journal of Clinical Pharmacology·S G CarruthersW H Aellig
Sep 15, 1995·Circulation·T Q KongA H Kadish
Jun 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·S A Bai, F P Abramson
Jan 1, 1986·European Journal of Clinical Pharmacology·M J JamiesonP H Flanagan
Jan 1, 1986·Journal of Pharmaceutical and Biomedical Analysis·R C Young, R W Nysewander
May 10, 1985·Journal of Chromatography·M AhnoffJ Vessman
Apr 1, 1977·The American Journal of Medicine·K H Stenzel
Oct 14, 2009·Clinical Biochemistry·Raffick A R BowenAlan T Remaley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved