Spurring radical reactions of organic halides with tin hydride and TTMSS using microreactors

Organic Letters
Takahide FukuyamaIlhyong Ryu

Abstract

Tributyltin hydride-mediated radical reactions of organic halides were successfully carried out in a continuous flow system using a microreactor. The reactions proceeded within a very short period of time, coupled with quickly decomposing radical initiators such as V-65 and V-70. The continuous flow reaction system was applied to gram scale synthesis of a key intermediate for furofuran lignans.

References

Feb 28, 2007·Journal of the American Chemical Society·Hirotsugu UsutaniJun-ichi Yoshida

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Citations

Aug 9, 2008·Chemical Communications : Chem Comm·Arjan OdedraPeter H Seeberger
Jun 11, 2009·Beilstein Journal of Organic Chemistry·Yoichi M A YamadaYasuhiro Uozumi
Sep 25, 2009·Beilstein Journal of Organic Chemistry·Takahide FukuyamaIlhyong Ryu
Sep 15, 2011·Beilstein Journal of Organic Chemistry·Aiichiro NagakiJun-Ichi Yoshida
Oct 7, 2011·Beilstein Journal of Organic Chemistry·Takahide FukuyamaIlhyong Ryu
Aug 21, 2012·Chemistry : a European Journal·Aiichiro NagakiJun-ichi Yoshida
Feb 13, 2013·Chemistry, an Asian Journal·Aiichiro NagakiJun-ichi Yoshida
Jun 10, 2008·Chemistry : a European Journal·Jun-ichi YoshidaTakeshi Yamada
Feb 19, 2010·Organic & Biomolecular Chemistry·Aiichiro NagakiJun-ichi Yoshida
Sep 8, 2010·Angewandte Chemie·Aiichiro NagakiJun-ichi Yoshida
Oct 30, 2010·Chemistry : a European Journal·Aiichiro NagakiJun-ichi Yoshida
Sep 26, 2013·Beilstein Journal of Organic Chemistry·Takahide FukuyamaIlhyong Ryu
Apr 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yusuke Takahashi, Aiichiro Nagaki
Sep 18, 2013·Chemical Communications : Chem Comm·Jun-ichi YoshidaAiichiro Nagaki
Mar 2, 2012·Chemistry, an Asian Journal·Aiichiro NagakiJun-Ichi Yoshida
May 15, 2013·Chemistry : a European Journal·Hannelore JaschMarkus R Heinrich
Dec 30, 2009·Organic Letters·Ananda HerathNicholas D P Cosford
Feb 5, 2009·Journal of the American Chemical Society·Aiichiro NagakiJun-ichi Yoshida
Oct 27, 2009·Organic Letters·Trine P PetersenTrond Ulven
May 9, 2009·Organic Letters·Inga C WienhöferIlhyong Ryu

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