Sputum and BAL Clara cell secretory protein and surfactant protein D levels in asthma

Allergy
Philip EmmanouilPetros Bakakos

Abstract

Clara cell secretory protein (CC16) is associated with Th2 modulation. Surfactant protein D (SPD) plays an important role in surfactant homeostasis and eosinophil chemotaxis. We measured CC16 and SPD in sputum supernatants of 84 asthmatic patients and 12 healthy controls. In 22 asthmatics, we additionally measured CC16 and SPD levels in BAL and assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, and epithelial detachment (ED) in bronchial biopsies. Induced sputum CC16 and SPD were significantly higher in patients with severe asthma (SRA) compared to mild-moderate and healthy controls. BAL CC16 and SPD levels were also higher in SRA compared to mild-moderate asthma. CC16 BAL levels correlated with ED, while SPD BAL levels correlated with SMA and RBM. Severity represented a significant covariate for these associations. CC16 and SPD levels are upregulated in SRA and correlate with remodeling indices, suggesting a possible role of these biomarkers in the remodeling process.

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Citations

May 10, 2016·Chest·Patrick D Mitchell, Paul M O'Byrne
Jun 19, 2016·The Journal of Allergy and Clinical Immunology·Stefano GuerraRichard J Martin
Mar 29, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J BiagioniC Carlsten
Feb 24, 2018·Frontiers in Medicine·Grith L Sorensen
Sep 12, 2020·Current Allergy and Asthma Reports·Youngwoo ChoiHae-Sim Park
Feb 20, 2018·Experimental and Therapeutic Medicine·Qian-Lin Yu, Zhangbo Chen
Dec 18, 2020·Journal of Clinical Medicine·Sultan AlmuntashiriDuo Zhang
May 1, 2021·International Journal of Molecular Sciences·Emanuela di PalmoAndrea Pession
Jun 8, 2021·The Clinical Respiratory Journal·Yuemei YangXin Yao
Aug 4, 2021·Allergy·Martine MootzUlrich M Zissler
May 9, 2018·Journal of Proteome Research·Dominic Burg The U-Biopred Study Group

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