Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients

The Journal of Allergy and Clinical Immunology
Michael D EvansNizar N Jarjour

Abstract

Various clinical, biologic, or physiologic markers of asthma have been used to identify patient clusters and potential targets for therapy. However, these identifiers frequently overlap among the different asthma groups. For instance, both eosinophil and neutrophil counts are often increased in the airways of asthmatic patients despite their typical association with type 2 and type 17 immune response, respectively. We sought to determine whether inflammatory gene expression is related to patterns of airway inflammation and lung function and identify molecular markers for neutrophilic asthma. Expression levels of 17 genes characterizing type 1, type 2, and type 17 lymphocytes were measured in sputum samples from 48 participants with asthma. The relationships between gene expression levels and sputum cell differentials or measures of pulmonary function were examined by using partial least squares regression. Gene expression levels were strongly associated with cell differentials, explaining 71% of variation in eosinophil counts and 64% of variation in neutrophil counts. The 3 genes with the strongest relationships to sputum neutrophil counts were IL1R1 (standardized regression coefficient [β] = +0.27, P = .005), IL1RAP (β = +0.32...Continue Reading

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Citations

Nov 14, 2018·Current Opinion in Pulmonary Medicine·Sven F SeysDominique M A Bullens
Nov 22, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephane EsnaultNizar N Jarjour
Nov 16, 2019·The European Respiratory Journal·Emmanuel T OseiTillie-Louise Hackett
Sep 23, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Weigang GanJuan Meng
May 16, 2020·Asia Pacific Allergy·Tomoyuki SomaMakoto Nagata
Mar 21, 2020·Frontiers in Pharmacology·Danila GurgonePasquale Maffia
Mar 25, 2019·Mediators of Inflammation·Stephane EsnaultNizar N Jarjour
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Jun 27, 2020·The European Respiratory Journal·Timothy S C HinksGuy G Brusselle
Sep 3, 2019·The Journal of Allergy and Clinical Immunology·Leonard B BacharierHirohito Kita
Dec 27, 2021·The Journal of Allergy and Clinical Immunology·Yan XieYaping Tu

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