Sputum colour can identify patients with neutrophilic inflammation in asthma

BMJ Open Respiratory Research
Kavita PabrejaJodie L Simpson

Abstract

Sputum colour is associated with neutrophilic inflammation in chronic bronchitis and chronic obstructive pulmonary disease (COPD). Neutrophilia and sputum expectoration is notable in asthma, but whether sputum colour is associated with and predicts the presence of neutrophilic inflammation in asthma is unknown. The objective of the study is to assess the ability of sputum colour in distinguishing asthma inflammatory phenotypes. Induced sputum samples collected from 271 adults with stable asthma were retrospectively assessed. Sputum colour was determined using the BronkoTest sputum colour chart and correlated to differential cell counts and CXCL-8 concentration. Neutrophilic inflammation was defined as an age-corrected sputum neutrophil proportion (≥61.6% for age 20-40 years; ≥63.2% for age 40-60 and ≥67.2% for age >60 years), whereas neutrophilic bronchitis (NB) was defined as high total cell count (≥5.1×10(6) cells/mL) plus an increased age-corrected neutrophil proportion. The optimal cut-off for sputum colour to predict neutrophilic inflammation and NB was determined using receiver operator characteristic curve analysis. A sputum colour score of ≥3 represented and predicted neutrophilic inflammation with modest accuracy (area...Continue Reading

Citations

May 8, 2018·BMC Infectious Diseases·Florian SalmUNKNOWN RAI-Study Group
Mar 6, 2021·NPJ Primary Care Respiratory Medicine·Sunita ChannaAlice M Turner

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Methods Mentioned

BETA
biopsies
pharmacotherapy
ELISA

Software Mentioned

BronkoTest
Stata

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