Sputum conversion at the end of 8weeks among category 1 tuberculosis patients: How reliable are the peripheral laboratory results?

International Journal of Mycobacteriology
Moses C AnyimSamuel B Olanisebe

Abstract

To assess the quality of week 8 sputum smear AFB microscopy performed by peripheral TB laboratories in Nigeria. A cross-sectional review was performed of all week 8 tuberculosis sputum smear slides reported for the first quarter of 2009 by peripheral laboratories in five States of Nigeria. Each slide was reviewed by two independent external slide readers as external quality check and also crosschecked with fluorescent microscopy. In Akwa Ibom, Anambra, Enugu, Kogi and Ogun States, a total of 415, 315, 231, 206 and 428week 8 slides respectively were studied (a grand total of 1595 slides studied). The wide range of conversion rates between the different States as reported by peripheral labs (83.8% in Anambra State to 98.1% in Kogi State) was also observed by the external quality check (68.4% in Kogi State to 88.0% in Akwa Ibom State). In all the States, the studied sputum conversion rates reported by the peripheral labs were significantly higher than values obtained from external quality check and fluorescent microscopy (P=0.000). There is a wide range of sputum conversion rates between States, but the conversion rate in each State is significantly higher than those of external quality check possibly indicating many false negativ...Continue Reading

References

Jun 6, 2007·Expert Review of Anti-infective Therapy·Karen R SteingartMadhukar Pai
Aug 8, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jann-Yuan WangUNKNOWN Tami Group
Sep 15, 2009·Journal of Infection in Developing Countries·Faruk SarkinfadaImelda Bates

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