Sputum induction in routine clinical care of children with cystic fibrosis

The Journal of Pediatrics
Suhail Al-SalehFelix Ratjen

Abstract

To determine the microbiological yield of induced sputum (IS) samples compared with conventional airway samples, spontaneously expectorated sputum and throat swabs, in children with cystic fibrosis (CF) attending an outpatient clinic. Ninety-five children with CF (75 able to spontaneously expectorate sputum) were included in this prospective cross-sectional comparative study. After obtaining expectorated sputum or throat swabs samples, IS was obtained by performing the sputum induction procedure using an eFlow device (PARI, Starnberg, Germany). CF bacterial culture results were compared between the two procedures. Differences in culture results between samples were observed in 25 of 94 (27%) patients. IS had a significantly higher yield for CF pathogens, with 80% of the differences being due to detection of additional organisms in IS samples. Overall, SI was well tolerated, but 12 of 95 cases had a >20% postinduction decline in forced expiratory volume in 1 second. The whole SI procedure took 30 to 85 minutes of clinic time, and its estimated additional cost was $150 (US)/patient. Induced sputum has a higher microbiological yield compared with the conventional samples in children with CF, even in patients capable of expectorati...Continue Reading

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Citations

Oct 15, 2013·Journal of Pediatric Gastroenterology and Nutrition·Giovanni Di NardoLaura Stronati
Jan 17, 2014·The Lancet. Respiratory Medicine·Hartmut Grasemann, Felix Ratjen
May 25, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jennifer RuddyMargaret Rosenfeld
Apr 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura L HammittUNKNOWN Pneumonia Methods Working Group
Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lindsay R GrantJ Anthony Scott
Sep 29, 2012·Science Translational Medicine·Paul C BlaineyStephen R Quake
Jul 2, 2011·American Journal of Respiratory and Critical Care Medicine·Jeremy A ScottHartmut Grasemann
Feb 1, 2011·American Journal of Respiratory and Critical Care Medicine·Hartmut GrasemannFelix Ratjen
Aug 21, 2012·American Journal of Respiratory and Critical Care Medicine·Scott D SagelEdith T Zemanick
Oct 17, 2012·PloS One·Hartmut GrasemannFelix Ratjen
Dec 18, 2013·Archives of Disease in Childhood. Education and Practice Edition·Bushra AhmedJane C Davies
Jan 8, 2015·Pediatric Pulmonology·Jordana E HoppeEdith T Zemanick
Jan 31, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Marco ZampoliBrenda Morrow
Sep 28, 2015·Paediatric Respiratory Reviews·Julian Forton
Feb 3, 2015·Pediatric Pulmonology·Harm A W M TiddensDavid A Waltz
Jul 16, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lisa SaimanDavid J Weber
Oct 11, 2016·Expert Review of Respiratory Medicine·Valerie WatersFelix Ratjen
Dec 4, 2016·Therapeutic Advances in Respiratory Disease·Marijke Proesmans
Jun 24, 2016·Global Pediatric Health·Ingeborg Y BartEsther de Vries
Dec 10, 2014·Pediatric Pulmonology·Michael Doumit, Adam Jaffé
May 30, 2015·The European Respiratory Journal·Peyman GhorbaniHartmut Grasemann
Dec 3, 2016·Journal of Breath Research·A H NeerincxR A Wevers
Jul 20, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·V Waters

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